44 pages • 1-hour read
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Content Warning: This section of the guide includes discussion of pregnancy loss, substance use, illness, death, gender discrimination, ableism, and child death.
“I try to teach them that making good decisions—in business, and in life—requires two things. First, they need all the information about the decision—they need the right data. Second, they need to think about the right way to weigh the pluses and minuses of the decision (in class we call this costs and benefits) for them personally. The key is that even with the same data, this second part—this weighing of the pluses and minuses—may result in different decisions for different people.”
This quote underscores two of the book’s central takeaways: Use Actual Evidence to Make Decisions but also Take Control of Your Pregnancy Choices. Oster’s approach moves beyond blanket rules by showing that even when evidence is clear, personal preferences, like risk tolerance or lifestyle priorities, can lead to different, equally valid choices. A pregnant person considering genetic screening, for example, may make a different decision than another person with the same risk profile, depending on how each one weighs the emotional, ethical, or medical implications.
“Starting pretty much the first day you menstruate, your fertility is declining. Your most fertile time is in your teens, and it goes down from there—30 is worse than 20, and 40 is worse than 30. But, of course, there are other factors that push you in other directions.”
This quote illustrates Oster’s commitment to challenging alarmist messaging. While she acknowledges the biological reality of age-related fertility decline, she also urges readers to consider broader life circumstances, such as emotional readiness, financial stability, or career goals, when making reproductive decisions. Rather than using fertility statistics to pressure people into early childbearing, Oster encourages a more individualized, balanced evaluation of timing and trade-offs, underscoring the key takeaway to Assess Risks in Context.
“Ultimately, virtually every woman I know has used at least some of these methods. Generally, people start with the temperature and move up to the pee sticks if a few months pass with no progress. Are these helpful? The data suggest yes, but for me probably the biggest benefit was just that they gave me a way to feel in control.”
This quote connects to the takeaway of taking control of one’s pregnancy choices. Oster highlights how tracking methods like ovulation tests can offer not just practical benefits but also psychological reassurance. Even when outcomes are uncertain, having tools that offer insight into one’s body can make the process of trying to conceive feel more manageable and empowering.
“But the tests that the researchers were using in this case were similar in their sensitivity to what is now available in the most sensitive home pregnancy tests. This means that a lot of the pregnancies that ended in early miscarriage and would not have been detected in the 1980s now probably would be (or at least could be).”
This quote underscores Oster’s point that using actual evidence is essential when interpreting modern pregnancy outcomes. For instance, rising rates of pregnancy loss may partly reflect improved test sensitivity, not an actual increase in rates. Understanding this distinction can help reduce unnecessary anxiety and promote more informed, data-literate responses to early pregnancy experiences.
“Ultimately, I concluded that these recommendations were not just very cautious, they were too cautious. In moderation, pregnant women should feel comfortable with both alcohol and caffeine.”
This quote reflects the key takeaway to Practice Moderation Instead of Blanket Avoidance. Oster critiques overly strict public health guidelines and encourages a balanced, evidence-based approach. Her message empowers readers to make informed choices by distinguishing between real risks and outdated or exaggerated warnings, like moderate caffeine or occasional alcohol, so long as decisions are grounded in good data.
“In my view, a reasonable person could see the case for reducing caffeine intake, and a similarly reasonable person could conclude that the results are probably all driven by differences in nausea and therefore continue on as before.”
Oster presents caffeine research as a case where reasonable people may interpret data differently, some opting for caution, others continuing as usual. This mirrors her broader argument for moderation over blanket avoidance. Rather than enforcing universal rules, she urges parents to assess the evidence, consider individual factors like nausea, and make context-specific decisions they’re comfortable with.
“There is positive evidence from at least one study in which women offered nicotine gum decreased the number of cigarettes they smoked. This study found that babies born to the women offered the gum had birth weights an average of 11 ounces larger than women who were not offered the gum. This is promising, but not conclusive.”
Oster points to nicotine gum as a potentially helpful tool for reducing harm in pregnancy, highlighting one study where it correlated with higher birth weights. This aligns with her broader message to assess risks in context; rather than framing smoking cessation as all-or-nothing, she encourages looking at incremental, evidence-based strategies that can lead to better outcomes. While not definitive, such findings support the idea that practical, data-informed compromises may be more effective than rigid prohibitions.
“You might wonder if there is something you can do (other than getting pregnant at 20 rather than at 35!). The answer is probably not. As most pregnancy losses at this point are due to chromosomal problems and those are determined at fertilization, it is out of your control.”
Oster emphasizes that many early pregnancy losses reflect chromosomal abnormalities present from fertilization, factors that lie beyond personal control. This reinforces her key message to focus on evidence, not blame. By highlighting what cannot be changed, she helps readers let go of misplaced guilt and redirect their energy toward informed decisions in areas where their choices do matter, such as prenatal care or lifestyle habits.
“It turns out that although many fish fall in the high mercury, high-omega-3 category, not all fish overlap. I ended up with a chart—an “Approval Matrix,” if you will—that maps out where various fish fall in the mercury-versus-DHA debate. The fish in the top right quadrant are the best: these are fish that are high in omega-3s but low in mercury, such as herring and sardines (small, oily fish) and salmon. Eating more of these fish can be nothing but good.”
Oster’s “Approval Matrix” approach to fish consumption illustrates her broader commitment to data-driven, individualized decision-making. By comparing mercury levels and omega-3 content, she shows how readers can move beyond vague warnings like “avoid fish” and instead make specific, safer dietary choices. This aligns with the book’s central takeaway to Question Conventional Pregnancy Advice and use actual evidence to guide decisions, whether choosing a prenatal supplement or deciding what’s for dinner.
“It’s possible that your doctor will be reluctant to prescribe you medication, or may first suggest you try eating smaller meals. But it increasingly seems to me that it’s the women who are reluctant to ask, who think they should suffer in silence. That’s not always a great idea: serious dehydration and weight loss during pregnancy can lead to complications. Why risk it when there are good, safe treatment options?”
Oster highlights a recurring idea in Expecting Better: Pregnant people are often encouraged, implicitly or explicitly, to endure discomfort rather than seek treatment. Her point here reinforces the key takeaway to take control of one’s pregnancy choices by urging readers to speak up, ask questions, and advocate for their well-being. Rather than framing nausea as something to simply “push through,” she underscores the risks of under-treatment and the availability of safe options, encouraging readers to treat their symptoms as valid medical concerns.
“The risk of miscarriage from the amniocentesis or CVS test is around 1 in 800. What you need to decide for yourself is whether having a baby with Down syndrome unexpectedly would be more than 125 times worse than having a miscarriage (that is, 100,000 divided by 800). If yes, then skip right to the invasive test—probably CVS given the timing. If no, then stick with the noninvasive screen. Of course, it’s not easy to answer this question, but it is the question you need to answer.”
Oster breaks down a deeply emotional decision, whether to pursue invasive prenatal testing, into a clear cost-benefit framework. This approach reflects the takeaway of assessing risks in context, showing how decisions in pregnancy are rarely about avoiding all risk, but rather about understanding and weighing the trade-offs that matter most personally. By translating abstract probabilities into a concrete comparison, she empowers readers to make informed, individualized choices rather than defaulting to standard protocols or fear-driven thinking. Her application of this approach to the highly charged topic of prenatal screening for disabilities exemplifies her desire to empower parents, some of whom may not be equipped to care for a child with Down syndrome, though it also leaves her open to charges of ableism.
“Somewhat surprisingly: although cat litter seems to have little risk, there is significant toxoplasmosis risk from gardening. That study in Europe that was reassuring on cats did find a strong association between toxoplasmosis and working with soil. This suggests that if you are planning to garden while pregnant you should use gloves, and possibly consider a mask to avoid inhaling any particles.”
Oster uses this example to demonstrate how widely accepted warnings, like the one about avoiding cat litter, can sometimes distract from greater, evidence-backed risks. The recommendation to wear gloves while gardening stems not from folklore but from actual study data, reinforcing the takeaway of using actual evidence to make decisions. Rather than relying on commonly circulated advice, Oster urges readers to shift focus toward verified risks and adjust their behavior accordingly, showing how data-driven thinking can lead to smarter, more practical precautions.
“Everyone had a story about their doctor giving them a hard time about their weight, mostly about gaining too much. One woman actually told me she switched to a midwife after her doctor commented too frequently on her weight gain.”
This account illustrates how medical advice, even when well-meaning, can feel judgmental or rigid when not paired with sensitivity or individualized care. It supports the takeaway of taking control of one’s pregnancy choices, encouraging readers to seek providers who respect their autonomy and concerns. Oster’s inclusion of such stories shows that finding a supportive care team isn’t just a preference; it can directly impact how empowered and respected a person feels throughout their pregnancy.
“In a 1995 study in the New England Journal of Medicine researchers reported on a cohort of women followed for months as they tried to conceive (we also referred to this study in the discussion of conception). There was no relationship between the timing of sex in relation to ovulation and the gender of the offspring. Sorry, you’ll just have to take your chances.”
This comment reinforces Oster’s broader message to use actual evidence to make decisions. The gender-timing myth persists in popular culture, but Oster shows that well-designed studies, like the one published in The New England Journal of Medicine, offer no support for such claims. Rather than relying on hearsay or anecdotal methods to influence outcomes, readers should focus on what science actually supports, letting go of unnecessary stress around factors that are ultimately random.
“A review article from 2009 suggests that women who are encouraged to do these exercises are less than half as likely as control women to experience any urinary incontinence during late pregnancy or in the postpartum period. This is especially true for women having their first baby.”
Oster highlights how simple, evidence-based interventions, like pelvic floor exercise, can lead to meaningful health improvements, especially for first-time parents. This supports the broader takeaway that pregnant people can take control of their pregnancy choices by adopting small, proactive habits rooted in credible research. Instead of waiting for complications like urinary incontinence to emerge, parents can take preventive steps early in pregnancy, demonstrating that informed choices aren’t limited to major medical decisions but extend to daily care and preparation.
“In layman’s terms, drugs are characterized as Category C if there is no actual evidence of risk, but there is also no large-scale human data. This includes drugs where there is evidence of harm in animal studies, and those with no animal studies. It includes drugs with some small human studies, and those with no human studies.”
Oster uses the example of Category C drugs to underscore a key takeaway: use actual evidence to make decisions. Rather than assuming that all Category C drugs are equally risky, she shows that this classification is broad and often misleading. Some drugs earn the label simply due to lack of data, not proven harm—an important distinction that can influence whether a pregnant person decides to take a medication. This example illustrates why understanding the nuance behind medical labels matters, especially when decisions involve balancing potential risk with quality of life.
“In a study of 1,200 women with singleton pregnancies and threatened preterm labor, about 400 of them were put on bed rest and the other 800 were not. Bed rest was not effective at preventing preterm birth (7.9 percent of the bed rest group and 8.5 percent of the control group had their babies prematurely). There’s more randomized evidence for multiple gestations, and again, there is no evidence that women put on bed rest had fewer preterm deliveries or better general outcomes.”
Oster uses the example of bed rest prescriptions to reinforce the takeaway of questioning conventional pregnancy advice. Despite bed rest being a widely recommended intervention for threatened preterm labor, randomized studies show that it does not significantly improve birth outcomes, even in higher-risk cases like multiple gestations. Nevertheless, many pregnant people continue to be told to restrict activity without clear evidence of benefit. This highlights the need for patients to ask not just what is being advised but why, as well as to request the data behind such recommendations before making disruptive changes to their lives.
“If you end up with a high-risk-pregnancy condition, your doctor is going to be your best resource. The treatments tend to be very specific to the individual—to your case and the particular details of your baby.”
Oster’s comment that “the treatments tend to be very specific to the individual” reflects the takeaway of assessing risks in context. While much of her book encourages questioning recommendations, she also recognizes that complex cases, like high-risk pregnancies, require tailored medical input. This reinforces the idea that data is not a substitute for clinical judgment but a complement to it. It also serves as a reminder that applying general advice without considering individual factors may be unhelpful or even harmful, particularly when navigating more serious pregnancy conditions.
“For women who were more than 60 percent effaced (that means shortened about halfway) at 37 weeks, almost all of them (something like 98 percent) went into labor before their due date. On the other hand, for women who were less than 40 percent effaced, almost none of them (less than 10 percent) went into labor before their due date.”
Oster’s interpretation of effacement data illustrates the takeaway of using actual evidence to make decisions. Rather than relying on vague estimates or anecdotal timing of labor, she encourages parents to understand specific clinical indicators, like cervical effacement, that offer statistically meaningful clues about when labor may begin. By translating this data into accessible terms, she empowers readers to interpret medical updates with more clarity and confidence, helping them set more realistic expectations in the final weeks of pregnancy.
“Breast stimulation causes your uterus to contract, and there is evidence that this can induce labor. A review article reported on four studies that randomized full-term pregnant women into a ‘breast stimulation’ or ‘no breast stimulation’ group and recorded whether they had gone into labor 3 days later. Of the breast stimulation group, 37 percent were in labor by 3 days, versus only 6 percent of those without breast stimulation!”
Here, Oster reinforces the book’s key message of using actual evidence to make decisions. She compares various natural labor-induction methods and points out that, among them, only breast stimulation has demonstrated measurable effects in randomized studies. While remedies like raspberry leaf tea or acupuncture are popular, she stresses that not all common practices are backed by data. For pregnant individuals hoping to induce labor naturally, this example shows the importance of checking whether a method is supported by credible evidence, not just anecdotal reputation, before relying on it.
“If you do decide to attempt a vaginal birth, be prepared: about half of attempted VBACs end in a C-section.”
This quote supports the takeaway of assessing risks in context. Oster acknowledges that while a vaginal birth after cesarean (VBAC) can be a safe and reasonable choice, it carries a substantial chance—about 50%—of ending in a repeat C-section. Rather than framing this outcome as a failure, she encourages readers to enter the decision with realistic expectations. For those weighing birth options after a prior C-section, this data point helps clarify trade-offs: A VBAC may offer benefits like shorter recovery or lower surgical risk, but it also comes with the possibility of an unplanned intervention. Informed preparation allows for better emotional and logistical planning, no matter the outcome.
“Same evidence, two different decisions, two happy moms. Knowing what the evidence says doesn’t make the decision for you. It just lets you make the decision in an informed way. The only mistake would be to decide one way or the other without thinking.”
This reflection comes after Oster shares her choice to forgo an epidural during labor while her friend made the opposite decision. She uses this anecdote to reinforce a core message of the book: to take control of one’s pregnancy choices. By emphasizing that the same data can support different decisions depending on individual values, Oster highlights that evidence should serve as a tool, not a prescription. The key is not which path one chooses but whether the choice is informed and deliberate. For readers, this reinforces the value of assessing information critically and then aligning decisions with personal comfort and goals, whether about pain relief, delivery method, or any other birth-related choice.
“Several randomized controlled trials have suggested that doulas have a large impact on birth outcomes. In one study, couples were randomly assigned to have a doula or not, starting at hospital admission. Women with a doula were half as likely to have a C-section (13 percent versus 25 percent) and less likely to use an epidural (64 percent versus 76 percent).”
This finding supports the takeaway of assessing risks in context by showing that better outcomes don’t always come from more medical intervention but from thoughtful support within the birth setting. Oster highlights how having a doula, someone offering continuous, non-medical support, can significantly reduce the chances of a C-section or epidural. These outcomes often depend not just on clinical need but on how hospitals deliver care. By presenting data from randomized controlled trials, Oster encourages readers to consider how institutional norms may influence risk and to look at alternatives that align more closely with their values and goals. It’s a reminder that making safer choices means understanding the full picture, not just following the standard path.
“Although the specter of childhood cancer is scary, the evidence is simply not there to support a link to vitamin K supplementation, and we know for sure that bleeding disorders are a risk.”
This example illustrates the importance of using actual evidence to make decisions rather than being guided by fear or anecdote. Oster addresses the common parental concern about a possible link between vitamin K shots and childhood cancer but clarifies that this fear is not supported by data. Meanwhile, the danger of bleeding disorders in newborns without vitamin K is well-established. Her point is not to dismiss parental instincts but to redirect them toward evidence-based thinking. Instead of fixating on unlikely risks, readers should weigh proven benefits and harms—a mindset that can guide countless decisions throughout pregnancy and parenting.
“Yet hospitals like that one are the reason that the maternal mortality rate in Nepal is a third of what it was thirty years ago, and the infant mortality rate is less than half. This is true for many reasons: the ability to have an emergency C-section if necessary, antibiotics to fight infection, Pitocin to ward off maternal hemorrhage, doctors who know how to maneuver a baby out of the birth canal if her shoulders get stuck, and so on. In the developing world, giving birth in a hospital is much, much safer than doing so at home.”
This passage supports the takeaway that assessing risks in context is essential for sound decision-making. Oster draws attention to the dramatic improvements in maternal and infant mortality in Nepal due to access to hospital-based care. Rather than advocating a universal stance on birth setting, she emphasizes that the safety of home versus hospital birth depends heavily on the resources, infrastructure, and emergency response capabilities of a given region. While home birth might be a reasonable choice in a well-equipped healthcare system with trained professionals, it carries far greater risks in low-resource settings. The quote urges readers to evaluate options not in isolation, but in light of local realities and available support.



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