It Starts with the Egg: How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF

In this chapter, Fett introduces myo-inositol as a supplement with particular relevance for those with PCOS or insulin resistance, though it may also benefit those with irregular ovulation, high FSH, or recurrent pregnancy loss. She explains that myo-inositol is a naturally occurring sugar molecule that plays central roles in insulin signaling, FSH responsiveness, and the conversion of testosterone into estrogen. Clinical studies consistently show that supplementation restores ovulation in individuals with PCOS, lowers testosterone, improves blood sugar regulation, and enhances egg and embryo quality in IVF contexts. Evidence also points to its role in reducing gestational diabetes risk during pregnancy and mitigating pregnancy loss risk associated with insulin resistance. Fett highlights its comparative effectiveness to Metformin, a widely used drug, while underscoring its safety and tolerability. She also distinguishes myo-inositol from D-chiro inositol, warning that the latter can worsen fertility outcomes when taken in large amounts.

Contextually, Fett’s argument reflects a larger medical trend of integrating metabolic health with reproductive outcomes, especially in conditions like PCOS that bridge endocrinology and gynecology. By framing myo-inositol as both safe and evidence-based, she positions it as part of a pragmatic toolkit for people navigating fertility challenges. Her reliance on clinical trial data lends credibility, but the chapter presumes awareness of diagnostic categories like insulin resistance or FSH testing—an assumption that may limit accessibility for readers without medical guidance.