Applegate reflects on the many blessings and tragedies she’s experienced throughout her life. She has often felt that every good thing has been followed by something devastating. She sometimes becomes preoccupied, wondering if she has brought tragedy on herself. She has tried to keep herself from thinking this way.

Applegate recounts her experiences starring in Samantha Who? and Dead to Me. She describes the positive female relationships she built through these shows. Then, while filming Samantha Who?, Applegate was diagnosed with breast cancer. She was devastated by how the diagnosis impacted her work but is retrospectively thankful for the care she received. She ended up having a double mastectomy, which saved her life. She excerpts her journal entries from this time, which reflect on her recovery. However, Applegate also regrets how she handled her cancer experience in the media. She wishes she had been more forthcoming about what she actually went through so that she could have better supported other women like her. She later started Right Action for Women, a foundation that covers cancer expenses, to amend this mistake. 

Not long after Applegate’s surgery, she learned that Samantha Who? would be canceled. She describes her sorrow over the end of this show.

Applegate asserts that despite all the difficulties of this time period, she was blessed to have LeNoble by her side. In 2010, she discovered that she was pregnant and recounts different memories of that time. She muses on how wonderful her daughter, Sadie, is and how much meaning she has brought to her life. She also stresses the significance of her and LeNoble’s love. They married in February 2013 and have been together ever since.

Applegate muses on her evolving regard for her father, Bob, over the years. She describes her positive relationship with Bob’s father, Paul, and his wife, Olive, throughout her life. However, Bob never knew his mother, and Applegate became curious to know her story, too. In 2013, she and Bob participated in Who Do You Think You Are?, “a genealogy-based TV show” (246). Through the show, she learned about her paternal grandmother, Lavina Shaw. She and Paul had a contentious, abusive relationship. Paul wouldn’t support Lavina after she got pregnant, convinced that Bob wasn’t his child. Lavina later died of tuberculosis and liver cirrhosis related to her alcohol addiction. Bob went to live with his father, who mistreated him throughout his life.

Applegate recalls conveying this information to Bob on the show and how much it hurt him. In retrospect, she realizes how much her father was a product of his difficult life, much like herself.

Applegate reflects on her acting experiences over the years. She describes her favorite jobs and how they made her feel about herself, including her experiences with the sitcom Friends, a benefit reading of Shakespeare’s Twelfth Night, and the 2016 comedy film Bad Moms.

Dead to Me has been one of her favorite projects. She describes the relationships she made on set and her enthusiasm for the show itself. While working on the show, however, Applegate started to struggle with filming. She couldn’t understand why. After seeing numerous specialists, she learned from a neurologist that she had MS. When Applegate informed the Dead to Me producers, they wanted to pause filming, but Applegate refused. Soon, however, she couldn’t manage her condition while working, and they had to end the show.

Applegate reflects on how losing this work and getting sick has changed her. Sometimes, while recalling the toxic expectation of modesty that she learned in childhood, she worries that she’s too proud of herself for all she has accomplished. Other times, she recognizes the value of her achievements.

Applegate reveals that her Hawaiian name is Kiki. Kiki feels like the true her now. While Christina Applegate represents her old self, Kiki is a more empowered, capable version of her.

Applegate reflects on her life and all that she has experienced and overcome. She describes her continued struggles with MS and simultaneous refusal to give up. In 2022, Applegate received what, for her, is the ultimate honor: a star on the Hollywood Walk of Fame. 

Applegate also muses on her relationship with her daughter, Sadie, whom Applegate values her more than anything in the world. She often lies in bed with Applegate. As she writes this now, Sadie is curled up next to her.