Mrs. Kranky leaves George home alone with Grandma and reminds him to give her medicine at 11 o'clock.

Grandma criticizes George for growing and eating chocolate, then hints she has magical powers.

George decides to make a powerful new medicine to replace Grandma's usual one.

George collects ingredients from rooms throughout the house and adds them to a large pot.

George adds animal medicines from the farm shed to give the mixture extra strength.

George boils the mixture on the stove and it produces blue smoke and a magical smell.

George takes brown paint from the toolshed and adds it to the mixture to disguise it as Grandma's medicine.

George gives Grandma a spoonful of his homemade medicine at exactly 11 o'clock.

Grandma grows taller and taller after taking the medicine until her head pokes through the roof.

George feeds medicine to a brown hen to prove it works, and the hen grows to the size of a horse.

Mr. Kranky has George give doses of medicine to farm animals, each of which grows to an extraordinary size.

A crane is called and operators lift Grandma free from the roof of the house.

Mr. Kranky announces his plan to mass-produce the medicine and sell it to farmers worldwide.

George and Mr. Kranky's repeated attempts to recreate the original medicine all fail to produce the same growing effect.

Grandma mistakes George's latest batch of medicine for tea, drinks it all, and shrinks into nothingness.

George, left home alone with his grumpy grandmother, decides to create a wild new medicine by mixing household products, animal medicines, and more. He replaces Grandma's regular medicine with his concoction, which causes her to grow to enormous size and break through the roof of the house. George proves the medicine's power on farm animals, and his father immediately becomes obsessed with the idea of mass-producing it to sell worldwide. Repeated attempts to recreate the original formula all fail, each producing strange and imbalanced results. When Grandma accidentally drinks the latest failed batch thinking it is tea, she shrinks away into nothingness. The family moves on quickly, while George is left in quiet awe of what he may have witnessed.

The core story of George's medicine and its extraordinary consequences.

Grandma demands George make tea to her exact specifications after Mrs. Kranky leaves for shopping.

Grandma describes eating slugs, beetles, and other insects, horrifying George.

George chants a poem imagining foul and disgusting ingredients while planning what to put in his medicine.

George adds bathroom products including toothpaste, shaving soap, face cream, and hair remover to the pot.

George adds kitchen spices including curry powder, mustard, chili sauce, and horseradish sauce to the mixture.

George dances around the boiling pot and spontaneously chants an incantation-like poem.

Grandma calls George a nasty little maggot from the living room while he secretly prepares his medicine.

Grandma shoots into the air and smoke pours from her nose after the first spoonful of medicine.

George pours water down Grandma's throat to stop the smoke coming out of her nose.

Grandma stands without support for the first time in years after the medicine takes hold.

Grandma asks for a second dose and George gives it to her, causing another burst of growth.

Mrs. Kranky returns from shopping and drops her groceries at the sight of giant Grandma and the giant hen.

The giant hen lays a football-sized egg after receiving a dose of George's medicine.

Freed from the roof by the crane, Grandma rides the medicine-enlarged pony around the farm.

Mrs. Kranky, upset at first about Grandma's disappearance, admits by lunchtime that it is all for the best.

After Mrs. Kranky leaves, Grandma's bossiness and disturbing talk of eating insects push George away and into the kitchen with a plan. He carefully selects ingredients from the bathroom and kitchen, imagining how each one might fix Grandma's many faults. He secretly swaps his concoction for her real medicine, and the first dose sends Grandma flying into the air with smoke pouring from her nose. After several alarming physical effects, Grandma experiences unexpected relief from her aches and stands freely for the first time in years before a second dose sends her crashing up through the attic. Mrs. Kranky comes home to find chaos, and the farm animals — including a hen that lays a football-sized egg — all grow huge after receiving the medicine. After Grandma's final disappearance, Mrs. Kranky quietly admits that life without her difficult mother will be easier.

The vivid details and discoveries behind George's extraordinary adventure.

Grandma beckons to George with her finger and he runs into the kitchen in fear and closes the door.

George decides to search every room in the house, adding every liquid, powder, and gooey substance he finds to the pot.

George passes the garage and adds engine oil, antifreeze, and grease to the pot on his way back inside.

Grandma swells like a balloon and then deflates as the first extraordinary effects of the medicine take hold.

Grandma's head crashes through the ceiling of George's room and into the attic after receiving a second dose.

George refuses to give Grandma a third dose of medicine and runs outside to watch from below.

Grandma claims her own magic, not George's medicine, caused her to grow.

Grandma shouts that she is still the tallest of them all after the hen grows to horse size.

Grandma sleeps in the barn that night after being freed from the roof, too large to fit in the house.

Mrs. Kranky warns that adding the same ingredients is not enough and that the amounts must also be correct.

Medicine Number Two is tested on a chicken, but only the legs grow to fifteen feet tall.

Medicine Number Three is tested on a rooster, but only the neck grows to six feet long.

Medicine Number Four causes a hen to shrink down to the size of a chick instead of growing.

Mr. Kranky encourages Grandma to drink what she thinks is tea, despite George and Mrs. Kranky's warnings.

George is left shaken and certain he has touched the edge of a magical world after Grandma vanishes.

George's fear of Grandma's claimed magical powers is what first drives him into the kitchen, where his plan takes shape. He makes a crucial decision to raid every room in the house systematically, then adds automotive fluids from the garage before boiling everything together. As Grandma takes her first dose, her body goes through a series of alarming physical changes — swelling, deflating, then shooting upward — before George refuses to give her a third dose and watches from outside. Grandma denies George any credit, insisting her own magic caused her growth, while subsequent batches mixed with Mr. Kranky all produce strange, imbalanced results — legs too long, neck too long, then shrinking altogether. Mrs. Kranky's warning that quantities matter as much as ingredients goes unheeded. Mr. Kranky's decision to encourage Grandma to drink what she mistakes for tea leads to her final disappearance, and George is left marveling at the magic he has touched.