Set in the waning days of the 1960s counterculture in Los Angeles, the novel follows Doc Sportello, a laid-back, marijuana-smoking private investigator in the fictional beach town of Gordita Beach. One evening, his ex-girlfriend Shasta Fay Hepworth appears at his door for the first time in over a year. She tells Doc she is involved with Mickey Wolfmann, a powerful real-estate developer, and that Mickey's wife Sloane and her boyfriend are plotting to commit Mickey to a mental institution to seize his fortune. Shasta has been asked to help lure Mickey but feels conflicted. She asks Doc to investigate, then disappears without leaving contact information.
Doc's Aunt Reet, a real-estate agent, warns him that Wolfmann surrounds himself with bodyguards from the Aryan Brotherhood, a white-supremacist prison gang. A second client, Tariq Khalil, a member of the Black Guerrilla Family, a militant Black prison organization, wants help collecting a debt from Glen Charlock, a white ex-convict working as one of Mickey's bodyguards. Tariq reveals that Channel View Estates, Mickey's housing development, was built on the demolished site of Tariq's old neighborhood, part of L.A.'s history of displacing communities of color. The development's commercials feature LAPD Detective Lieutenant Bigfoot Bjornsen, Doc's longtime antagonist, a hippie-hating cop with show-business ambitions.
Doc goes to Channel View Estates seeking information about Glen but loses consciousness under mysterious circumstances. He awakens at a crime scene: Glen has been shot dead, Mickey has vanished, and Bigfoot treats Doc as the prime suspect. Doc's lawyer, Sauncho Smilax, a maritime-law attorney, secures his release. Shortly after, Bigfoot informs Doc that Shasta has also disappeared.
Hope Harlingen, who is recovering from heroin addiction and raising her toddler daughter Amethyst, seeks Doc's help. She does not believe her husband Coy Harlingen, a surf-band saxophonist, truly died of an overdose months earlier. Doc takes the case and learns Coy may be living in disguise among the entourage of the Boards, a surf-rock band in Topanga Canyon.
Posing as a psychiatric clinic representative, Doc visits Sloane Wolfmann and meets Riggs Warbling, her "spiritual coach" whom Doc suspects is also her lover. Penny Kimball, a deputy DA Doc has been casually seeing, delivers him to FBI agents who question him about Tariq and Black Nationalist groups. That evening, at Club Asiatique in San Pedro, Doc watches Vietnam veterans negotiate with Blondie-san, an intermediary connected to a shadowy network called the Golden Fang. In the parking lot, he encounters Coy alive. Coy tells him the Golden Fang is a schooner involved in smuggling. Sauncho, whose firm has been investigating the vessel, reveals its history of Cold War espionage and CIA heroin running. An intelligence contact confirms that both Mickey and Shasta departed aboard the schooner.
During an acid trip, Doc envisions Shasta aboard the Golden Fang, held under duress. Aunt Reet identifies the Chryskylodon Institute, a private psychiatric facility in Ojai funded by Mickey's savings-and-loan empire. A limo driver named Tito Stavrou reveals he was the last person to speak with Mickey, who called terrified from near Chryskylodon but never showed for a pickup. Tito adds that "Chryskylodon" is Greek for "gold fang."
At a televised Nixon rally, Doc recognizes a supposed protester dragged away by operatives as Coy, working undercover as an LAPD informant. Coy confides that he joined Vigilant California, a right-wing patriotic organization, seeking sobriety but now sees it as an apparatus of control that has cost him his family. Doc tours Chryskylodon undercover, spotting Coy among robed figures in an underground observation area and finding an orderly wearing one of Mickey's personal effects, confirming Mickey was processed through the facility.
Doc visits the Golden Fang Enterprises headquarters on lower Sunset Boulevard, a building shaped like a giant golden fang. Inside, he meets Dr. Rudy Blatnoyd, a dentist and Golden Fang partner, and encounters Japonica Fenway, the troubled daughter of a wealthy family whom Doc once rescued as a runaway. Japonica has been repeatedly committed to Chryskylodon by her parents, and the institute has become a predatory institution. Shortly after this visit, Bigfoot reports Blatnoyd dead with suspicious puncture wounds. Clancy Charlock, Glen's sister, connects Doc with Boris Spivey, another of Mickey's former bodyguards, who reveals Mickey had been planning to give away his fortune. Boris confirms the Channel View assault was a setup: A bodyguard named Puck Beaverton was supposed to let the attackers in but switched shifts with the unsuspecting Glen. Cars surveilling Shasta are traced to the LAPD's civilian police reserves, a private militia used for off-the-books operations.
Bigfoot steers Doc toward Adrian Prussia, a loan shark with deep LAPD connections. Sealed records reveal that Prussia murdered Detective Vincent Indelicato, Bigfoot's longtime partner, and walked free on a plea bargain. Doc realizes Bigfoot has been maneuvering him to investigate Indelicato's murder from outside the department.
In Las Vegas, Doc glimpses Mickey tranquilized and escorted by FBI agents. At Arrepentimiento, Mickey's abandoned utopian housing project where anyone could live for free, Riggs Warbling reveals that Mickey has been "reprogrammed" at Chryskylodon, reunited with Sloane, and has withdrawn all funding from the project.
Shasta reappears in Gordita Beach, telling Doc her relationship with Mickey is over. Doc learns the Golden Fang is also an Indochinese heroin cartel running a vertically integrated operation from growing to laundering money through fronts like Chick Planet Massage. Tariq and Clancy, now in a relationship, reveal that Glen's death stemmed from a collapsed prison deal involving Golden Fang-supplied firearms. Doc also discovers that El Drano, the dealer who supposedly sold Coy the fatal dose, was paid by Mickey's institutions to supply heroin for Coy's staged overdose.
Doc visits Adrian Prussia's office and finds Puck waiting. Puck drugs and restrains Doc, then reveals Glen was the real target of the Channel View raid; Mickey simply stumbled into the scene. Puck also confesses to shooting Detective Indelicato on Adrian's orders. When Puck prepares a lethal injection, Doc frees himself, beats Puck unconscious, and shoots Adrian. Bigfoot arrives, loads 20 kilos of Golden Fang heroin into his car, and secretly plants the drugs in Doc's trunk.
Doc hides the heroin in the fire-damaged apartment of his friend Denis. Crocker Fenway, Japonica's powerful father and a fixer for the Golden Fang, demands the drugs' return. Doc negotiates: He will return the heroin for guarantees that Coy will be released from his obligations to Vigilant California and the LAPD. At the exchange in a shopping-mall parking lot, a Golden Fang operative hands Doc a credit card in Coy's name, a symbolic pass back to civilian life.
Shasta confesses to Doc that she connected Coy with Burke Stodger, the blacklisted actor who introduced Coy to Vigilant California in exchange for undercover work as an informant. She reveals she was taken against her will aboard the Golden Fang but escaped when the schooner reached Maui. She challenges Doc to consider whether he has been serving the same controlling interests he claims to oppose.
In the novel's final movement, the Golden Fang schooner is pursued by the Coast Guard and abandoned by its crew. Hope calls with joyful news: Coy has been reunited with his family and is off every payroll. Doc drives home through thick coastal fog, falling in behind another car's taillights as someone else falls in behind him, forming an anonymous convoy of strangers navigating the blindness together. The novel closes with Doc imagining this temporary commune of drivers, a fleeting act of mutual trust, and wondering what might be there when the fog lifts.