Leto is the nine-year-old son of Paul Atreides and Chani. Because his mother consumed large amounts of spice during pregnancy, he is pre-born, endowed with the ego-memories of all his ancestors. Physically a child but mentally ancient, he wrestles with the threat of Abomination, or possession by his inner personas, while searching for a path to ensure his empire's future.

Ghanima is Leto's twin sister, also a pre-born carrying the consciousness of her ancestors. Compassionate and mature beyond her nine years, she strongly identifies with her Fremen heritage. She works closely with Leto to avoid the fate of Abomination and survive the treacherous political environment surrounding their powerful bloodline.

Alia is the twenty-four-year-old regent of the Atreides empire, governing Arrakis during her brother Paul's absence. As a pre-born, she faces intense pressure to maintain order among dissenting factions and ambitious rivals. Isolated by her unique condition, she constantly fights to silence the aggressive ancestral voices demanding control over her mind.

Lady Jessica is the mother of Paul and Alia and a highly trained member of the Bene Gesserit sisterhood. She travels from Caladan back to Arrakis to investigate rumors that her daughter and grandchildren have succumbed to Abomination. Pragmatic and strictly disciplined, she frequently prioritizes political strategy and her Bene Gesserit conditioning over familial sentiment.

Once the revered Emperor and messiah known as Muad'Dib, Paul wandered blind into the desert and was presumed dead. Now, a mysterious blind man known as The Preacher stands in the public plazas of Arrakeen, condemning the religious idolatry built in Paul's name. His sudden appearance sparks widespread rumors that the former ruler has returned to dismantle his own legacy.

Stilgar is the Naib of Sietch Tabr and a respected Fremen leader. Appointed as the official guardian of Leto and Ghanima, he finds himself conflicted by his duties to the Atreides government. He watches with dismay as rapid terraforming projects erase the harsh desert environment that once defined Fremen culture.

Farad'n is the nearly eighteen-year-old grandson of the deposed Emperor Shaddam IV. Living on the planet Salusa Secundis, he is the rightful heir to House Corrino. While his mother plots violent schemes to reclaim the imperial throne, Farad'n prefers studying Atreides history and philosophy over military conquest.

The deceased Baron Harkonnen is the ancient, brutal enemy of the Atreides family and Alia's maternal grandfather. He exists as a malicious ego-memory within the minds of the pre-born. He exploits Alia's deep insecurities, offering false promises of political guidance while secretly maneuvering to dominate her consciousness.

Duncan is a ghola, a genetic replicant of the original Atreides swordmaster, brought back to life with the analytical abilities of a mentat. He serves as Alia's husband and trusted advisor. Bound by a deep, inherent loyalty to the Atreides family, he grows increasingly disturbed as he observes dangerous shifts in his wife's behavior.

Princess Wensicia is the ambitious daughter of the late Emperor Shaddam IV. Operating from exile on Salusa Secundis, she aggressively schemes to restore House Corrino to power. She utilizes trained beasts and secret alliances to execute assassination plots against the Atreides bloodline.

Gurney is the former Warmaster of House Atreides and a skilled troubadour. He acts as a fiercely loyal protector and enforcer for Lady Jessica. Following her strict orders, he travels into the deep desert to test the young Leto for signs of Abomination.

Irulan is the daughter of the deposed Emperor Shaddam IV and the former wife of Paul Atreides. Having severed her ties with the Bene Gesserit sisterhood, she dedicates herself to protecting Leto and Ghanima, acting as a devoted surrogate mother to the twins.

Javid is a high-ranking priest operating within Alia's inner circle on Arrakis. While outwardly devoted to the dominant religion of Muad'Dib, his actions are driven by political opportunism. He acts as a covert accomplice for external factions seeking to undermine the Atreides regime.

Tyekanik is a dedicated military aide serving House Corrino on Salusa Secundis. He works closely with Princess Wensicia, managing the tactical details of her covert assassination plots and preparing the Corrino forces for potential conflict.

Assan is a fourteen-year-old Fremen boy from the outcast community of Shuloch. He serves as the primary guide for the blind Preacher, leading him through the harsh desert and the crowded streets of Arrakeen.

Muriz is a prominent figure among the Cast Out, an exiled community of Fremen living in secret desert sietches. He strictly enforces his tribe's brutal traditions and oversees their hidden operations in the deep desert.

Namri is a stern Fremen schoolmaster residing in the legendary, hidden domain of Jacarutu. Operating under secretive orders, he administers rigorous and often deadly tests to determine if captives possess true Fremen values or have fallen to Abomination.

Sabiha is a young Fremen woman living in the outcast community of Jacarutu. She is assigned to monitor and feed Leto while he endures the intense spice trance.

Chani is the deceased Fremen partner of Paul Atreides and the mother of Leto and Ghanima. She exists as a benevolent ego-memory within the minds of her pre-born children, offering them vital counsel and emotional protection against more malicious ancestral voices.