Dog Man is a police officer created when a police dog’s body and a policeman’s head were injured and surgically combined. He possesses a kind heart and a strong desire to do good in his community. However, his uncontainable canine tendencies—like digging up gardens, licking people, and chewing objects—frequently cause comic mayhem and land him in trouble with authority figures.

Petey is a striped cat and former villain who is attempting to live a better life. He struggles with deep-seated anger and resentment, particularly toward his father, who abandoned him and his mother. Throughout the story, he wrestles with the choice between harboring hatred and learning to forgive.

Li'l Petey is a small striped cat who is the cloned son of Petey. He is an inherently kind, optimistic, and forgiving child who loves drawing and participating in his Comic Book Club. His boundless capacity for love serves as a guiding light for the older, more cynical characters around him.

Grampa is a striped cat and an unrepentant, long-standing criminal. He is highly intelligent and constantly schemes to cause destruction and exact revenge on society. Selfish and abrasive, he feeds on the anger of others and uses his inventions to amplify his own malicious nature into the supervillain Crud.

The Mayor is the temperamental and easily angered leader of the city. He is highly protective of his pristine rose bushes and holds a bitter grudge against Dog Man for his disruptive, dog-like behavior. His focus on punishing Dog Man often blinds him to the actual dangers threatening his city.

George is a fourth-grade student who co-creates the Dog Man comic books alongside his best friend. He is highly creative and acts as the writer of the pair, plotting out the wild and silly adventures that unfold in their comics.

Harold is a fourth-grade student and the best friend of George. He serves as the illustrator for their popular Dog Man comic books. He possesses a vibrant artistic talent that brings their silly, imaginative stories to life for their fans.

The Police Chief is the head of the local police department and Dog Man's boss. He is deeply devoted to Dog Man, often acting as his protector and advocate when things go wrong. He is highly emotional and openly weeps when separated from his favorite canine officer.

80-HD is a highly capable robot who lives with Petey and Li'l Petey. Unable to speak verbally, he communicates through demonstrative actions and art. He is an invaluable ally who helps build creative inventions and protect the city from threats.

Big Jim is Grampa's large, simple-minded, but inherently sweet grandson. He is desperate for affection and approval, making him an easy target for Grampa's manipulation. When equipped with the Motor Brain, his loving nature amplifies, turning him into the extremely affectionate entity known as Snug.

Munchy is initially the city's 3rd Largest Lunch Bag before being animated by Grampa's living spray. As a giant, living entity, he terrorizes the city and eats buildings until a group of children creatively intervene to change his disposition.

Molly is a young tadpole and a member of the Comic Book Club. She is an avid artist who approaches frightening situations with creativity and love rather than fear, proving instrumental in defusing city-wide threats.

Flippy is an adult fish who works as a teacher for the local pond youths. He is fiercely dedicated to education, even shouting out grammar instructions while being grabbed by a giant monster.

Sarah is a local news reporter who covers the major events and monster attacks in the city. She acts bravely during crises, actively trying to assist the police and save those in danger while broadcasting the news.

Gramma is Petey's deceased mother. She was deeply loved by her son but was mistreated and abandoned by Grampa. Her memory continues to influence Petey's emotional struggles.

Mr. Snookums is the Mayor's beloved teddy bear. He serves as the Mayor's silent confidant and most prized possession, representing the Mayor's softer, albeit childish, side.