Dog Man is a dedicated police officer who possesses the head of a dog and the body of a man. Known for his kind heart and physical bravery, he occasionally succumbs to dog-like behaviors, such as drinking from the toilet bowl, which leads to his current comedic predicament. He relies heavily on his community for emotional and practical support when he feels embarrassed by his medical cone.

Petey is a striped cat and a reformed villain working to build a positive, law-abiding life for his family. Despite his criminal past, which was fueled by societal rejection, he now draws on the memory of his mother's unconditional love to be a good father. He struggles to maintain patience when his son's chaotic playdates interrupt his attempts at professionalism.

Li'l Petey is a small striped cat who acts as Petey's son, though he is technically a clone. He is a curious, good-natured child with a penchant for silly toilet songs and creative problem-solving. He serves as the emotional core for his father, consistently reminding the adults around him about the importance of love over material possessions.

Chief leads the local police force and serves as Dog Man's fiercely devoted supervisor and friend. He is prone to hyperbolic reactions, particularly regarding the physical safety of his officers and his own blossoming romantic feelings. He frequently finds himself needing rescue despite his authoritative role in the town.

Grampa is Petey's estranged, villainous father who abandoned his family years ago. He is a maniacal figure focused entirely on destruction, disruption, and achieving his own selfish desires. He relies heavily on manipulating his gullible cellmate to execute his chaotic plans against the city.

Big Jim is an endearingly unintelligent inmate who shares a cell with Grampa and possesses a superhero alter ego. He is utterly obsessed with cupcakes and allows this fixation to cloud his judgment. Despite Grampa's constant verbal criticism, Big Jim remains remarkably kind-hearted and desperately seeks his cellmate's genuine friendship.

Molly is a small green tadpole and a highly playful child who completely disregards standard social boundaries. She thoroughly enjoys singing loud toilet humor songs with her friends. Her eccentric demeanor hides a surprisingly nonchalant attitude toward the chaos erupting in the city.

Nurse Lady is a medical professional who treats the town's strange injuries and provides steady care in a chaotic environment. She is the direct object of Chief's intense affection and finds his quirky personality endearing rather than off-putting.

80-HD is a highly capable robot built by Petey who serves as a loyal, mechanical companion. The robot cannot speak verbally but expresses itself brilliantly through mechanical engineering and physical art. It represents the power of neurodivergent creativity, constructing incredible inventions out of everyday objects to help those in need.

Sarah Hatoff is an investigative journalist documenting a former villain's transition into a law-abiding citizen. She operates with intense focus and tends to pepper her subjects with rapid-fire questions without waiting for their answers.

George Beard is an elementary school student who serves as the in-universe co-creator of the comic books detailing the town's adventures.

Harold Hutchins is an elementary school student who works closely with his best friend to write and illustrate their wildly imaginative comic series.