Josh Thistle is Jesse Thistle's oldest brother. Protective of Jesse in their youth, Josh later diverges onto a different life path, joining the Royal Canadian Mounted Police, and distances himself due to Jesse's destructive behavior. He maintains affection for Jesse, evident when attending his wedding.

Jerry Thistle is Jesse Thistle's older brother. Like Josh, Jerry is protective of Jesse during childhood but also grows apart from him due to Jesse's lifestyle choices. He remains supportive, visiting Jesse in prison.

Cyril Thistle is Jesse's paternal grandfather. He is a firm believer in hard work and family, instilling these values in his grandsons. Despite harsh treatment, his intentions stem from concern for Jesse's future.

Jackie Thistle is Jesse's paternal grandmother, expressing love more readily than Cyril. She shows affection and support for Jesse, even when he faces difficulties, leaving a lasting impact on him.

Blanche Thistle, Jesse's mother, is Métis-Cree. She leaves the family early on, and her sporadic visits contribute to Jesse's feelings of abandonment. Their relationship improves when Blanche reaches out to support him during recovery.

Sonny Thistle is Jesse's father, of Algonquin-Scot descent. He is largely absent from Jesse's life due to his abusive and neglectful behavior, but Jesse later finds connection through letters Sonny wrote.

Karen is Jesse Thistle's high school girlfriend, providing stability and acceptance during a challenging time in his life.

Lucie is a supportive figure in Jesse's life as he turns things around at Harvest House. A childhood acquaintance, she stands by him and encourages his positive changes, eventually becoming his wife.