Shi Meiling is Yunxian’s lifelong friend and the only daughter of Midwife Shi. Energetic and compassionate, she learns from Yunxian how to behave like a fine lady. Meiling shares much with Yunxian, including the compilation of her medical book, and is grateful for Yunxian’s help in conceiving a child.

Grandmother Ru is part of Yunxian’s circle of women and comes from a line of hereditary doctors. She mentors Yunxian, teaching her Traditional Chinese Medicine and encouraging her friendship with Meiling. Grandmother Ru’s guidance helps Yunxian grow into her role as a doctor.

Lady Kuo is Yunxian’s strict and dutiful mother-in-law, ruling over her household with authority. She values obedience and duty, sometimes at the cost of personal health and happiness. Her adherence to tradition creates tension with Yunxian’s ambitions.

Miss Zhao, a concubine in Master Tan’s household, provides Yunxian with guidance and support. Though her role is traditionally limited, Miss Zhao becomes a nurturing figure for Yunxian, traveling and assisting her in times of need.