Charles is a widower who relocates to his ancestral summer home, Chaplewaite, following the death of his wife. He hopes the remote Maine estate will aid his mental recovery. Though he initially views the locals' fears of the property with amusement, his curiosity about the estate's history pulls him into dangerous occult mysteries.

Hall is a college-educated drifter who works a menial industrial job. He passes the time by pegging stray rats with empty cans and keeps to himself. When forced to clean the mill's deeply infested basement, his quiet resentment toward his abusive manager boils over.

Warwick is a petty and abusive foreman at a decaying textile mill in Gates Falls. He despises his educated employees and constantly belittles them. His determination to maintain authority blinds him to the escalating dangers beneath the factory floor.

Bernie is a young man in his twenties living through a deadly global pandemic. He spends his days reminiscing about past beach vacations and observing the decaying ruins of society. His internal thoughts reveal a growing distaste for his companions and a dark cynicism about their chances of survival.

Arthur is a paraplegic former astronaut living in Key Caroline. Following a mission where he transited the backside of Venus, he crashed back to Earth and sustained severe injuries. He undergoes years of recuperation but soon discovers that an alien presence has taken root in his body.

John is a police detective tasked with investigating a series of bizarre deaths involving a large laundry folding machine. He is a straightlaced man who relies on modern investigative techniques. However, the inexplicable nature of the accidents slowly erodes his confidence in logic and reason.

Lester is a 28-year-old divorced man working in a warehouse. He carries immense guilt and anger over the deaths of his three young children, which he attributes to a monster in the closet. He harbors rigid expectations for masculinity and openly resents the responsibilities of parenthood.

Richie is a former mill worker living on permanent disability following a workplace accident. After consuming a tainted can of cheap beer, he becomes incredibly sensitive to light and refuses to leave his apartment. He relies entirely on his terrified son to supply him with alcohol.

John is a highly efficient professional assassin. He relies heavily on his military background and rational mind to survive his dangerous line of work. His lucrative career provides him with a posh lifestyle, but his methodical nature is tested when he receives an unusual package.

Jim is a high school English teacher who struggles with traumatic memories of his brother's murder. He attempts to move forward by taking a job at a new school. His past begins to haunt his present when familiar, threatening faces appear in his classroom.

Larry is an upwardly mobile lawyer working in a city far from his rural roots. He has spent years prioritizing his career over his familial relationships. The sudden loss of his sister forces him to re-evaluate his life choices and confront a childhood memory of saving her life in a barn.

Kitty is a former beauty pageant winner whose life spiraled downward after moving to Hollywood. Growing up in Nebraska, she shared a deep bond with her brother, trusting him completely during their childhood games. In adulthood, she struggles with failed marriages and isolation as she drifts away from her family.

Johnny is a grieving son struggling to maintain his childhood home while his mother battles terminal stomach cancer. He turns to alcohol to cope with the emotional toll of his caretaking duties. He frequently relies on pop culture references to process his overwhelming situation.

Elizabeth is an ambitious college student facing the societal pressures of maturity and conventional domestic life. She desires independence but struggles to decipher the true intentions of the men around her. She finds herself strangely drawn to an awkward classmate who seems to anticipate her every desire.

Ed is a disheveled and awkward college student with an eidetic memory. He uses his strange talents to anticipate the exact needs of the woman he desires. Raised by unstable parents, he develops controlling habits masked as perfect devotion.

Burt is a man trapped in a fractious marriage, hoping a cross-country vacation will save his relationship. His stubbornness drives him to investigate a deserted farming town after a horrifying accident on the road. He insists on following the rules of society even when surrounded by alarming circumstances.

Isaac is the nine-year-old leader of an agrarian youth cult in Gatlin, Nebraska. He commands absolute authority over the other children, interpreting the will of a mysterious deity that lives in the crops. He enforces strict rules that demand the sacrifice of anyone reaching adulthood.

Stan is a 36-year-old tennis professional with a past criminal record for breaking and entering. He is in love with a powerful man's wife, which places him in a deadly predicament. To secure his freedom and his relationship, he must perform a terrifying physical challenge high above the city streets.

Cressner is a wealthy and malicious crime boss who closely surveils his wife. He delights in asserting his power over others through high-stakes bets. He utilizes his vast resources to trap his enemies in impossible, deadly situations.

Richard is an anxious, middle-class professional struggling to quit smoking. Work stress frequently pushes him toward bad habits. Desperate for a solution, he enrolls in a highly secretive and extreme self-improvement program that promises results through unconventional methods.

Vic is a blunt, aggressive counselor running a highly secretive self-improvement program. He relies on extreme aversion therapy and constant surveillance to ensure his clients meet their goals. He speaks plainly about the terrifying consequences of failure.

Harold is a suburban homeowner who takes pride in his property but lacks a working mower. He idolizes wealthy financial CEOs and views them as modern demigods. His decision to hire an independent mowing service introduces a chaotic and ancient force into his quiet life.

Booth is a weary local man who lives on the outskirts of an abandoned, ruined town. He is acutely aware of the supernatural dangers lurking in the nearby woods and takes precautions to protect himself. Despite his fear, he possesses a strong sense of duty toward strangers in need.

Calvin is the loyal attendant to Charles Boone. He discovers an old map to the abandoned village of Jerusalem's Lot while tidying the house. Though he supports Charles, he grows increasingly fearful of the supernatural occurrences in the home.

Dr. Harper is a psychiatrist treating a deeply disturbed patient. He interjects quietly during the session, attempting to guide the conversation toward the truth of the man's family tragedy. He maintains a calm, clinical demeanor while hearing horrifying confessions.

Timmy is a frightened young boy trapped in an abusive cycle with his father. He dutifully runs errands for his father but grows increasingly terrified by the changes occurring in their dark apartment. He eventually seeks help from the working-class men at the local store.

Vicky is a young woman traveling cross-country with her husband, painfully aware that their marriage is failing. She is deeply unsettled by religious radio broadcasts and begs her husband to avoid the deserted town of Gatlin. Her instincts prove correct as they encounter danger.

Tookey is a practical bar owner in a small Maine town. He understands the dark history of the neighboring ruined village and keeps religious artifacts on hand for protection. He bravely accompanies a friend into the storm to help a stranded motorist.