Shakbatina is a Choctaw Inholahta, or peacemaker, in the 18th century. She prioritizes the preservation of peace and the protection of her people above all else, willingly offering herself as a sacrifice to stop an impending war sparked by her son-in-law's actions. Following her physical death, she becomes a powerful guardian spirit who actively works to guide her family across centuries.

Auda is a respected Choctaw historian and academic in the 20th century. Her 18th-century counterpart, Anoleta, is Shakbatina's eldest daughter. Both women share a fierce loyalty to their tribe but find themselves romantically entangled with charismatic, powerful men who eventually betray the Choctaw people. Driven by a deep love for their community, they must find ways to stop the men they love from destroying their tribe.

Red Shoes is a deadly 18th-century Choctaw warrior whose dealings with European colonizers incite deep conflict. His 20th-century counterpart, Redford McAlester, is the Chief of the Oklahoma Choctaws. Both men possess immense charisma and begin with a desire to empower their tribe, but their ambitions quickly warp into dangerous greed and corruption.

Isaac is a respected Choctaw elder and World War II veteran. He is also a successful rancher who publishes a tribal newspaper. He mentors younger members of the community and holds a traditional, protective uncle role over his nieces. He carries deep regrets about a lost romance from his youth and uses humor and feigned ignorance as tools to manage outsiders.

Tema is a successful stage actor living in Dallas, Texas. Her 18th-century counterpart, Haya, is the younger sister of Anoleta, initially training to become a peacemaker. Both women exhibit a strong connection to their heritage and step fiercely into protective roles when their older sisters face mortal danger.

Adair is a highly successful Wall Street stockbroker living in New Orleans, often referred to as the Wall Street Shaman by her clients. Her counterpart, Neshoba, is the third of Shakbatina's daughters. Both women use their unique talents and sharp instincts to gather resources and protect their loved ones behind the scenes.

Susan is the matriarch of the modern-day Billy family and a survivor of the abusive Indigenous boarding school system. She recognizes the corrupt nature of Chief Redford McAlester early on, creating a temporary rift with Auda. When crisis strikes, she demonstrates absolute devotion to her family.

Delores is a former Hollywood actress and an Indian-way aunt to the Billy sisters. After surviving an abusive boarding school and performing in a Wild West show, she devoted herself to reviving ancient, traditional Choctaw funeral rites. She possesses profound spiritual intuition and works to guide the souls of the dead.

Dovie is Delores's eccentric sister and business partner. She reads tea leaves and practices tai chi. She speaks often of Atlantis and herbal cures, bringing a unique kind of spiritual wisdom to her community.

Koi Chitto is Shakbatina's devoted husband and the father of Anoleta, Haya, and Neshoba. He holds the solemn duty of being a Bone Picker, responsible for traditional Choctaw funeral rites. He travels extensively and relies on profound spiritual visions to guide his actions during crises.

Gore is an aspiring lawyer who shares a brief, intense connection with Adair before disappearing from her life. He later re-enters the picture as a highly capable defense attorney for the Billy family, offering legal strategy and emotional support.

Carl is the acting chief of the Choctaw Nation following Redford McAlester's death. He is deeply entangled in Redford's corrupt dealings with the mafia and struggles to manage the intense fallout left behind in the wake of the chief's murder.

Hoppy is Tema's son and the great-nephew of Isaac. He is a young man learning to understand his Choctaw heritage and familial responsibilities. Guided by his uncle, he begins to see the deeper spiritual currents affecting his family.

An enigmatic elderly woman who appears as a trickster figure and shapeshifter within the Choctaw community. Drawing parallels to the legendary French actress Sarah Bernhardt, she channels ancient spirits, specifically the Great Mother Porcupine, to offer unconventional wisdom and protective visions to the Billy family.

Nitakechi is Shakbatina's brother and an 18th-century elder who helps his family manage the mounting tensions with Red Shoes and the encroaching colonizers. He serves as a trusted confidant to Koi Chitto and a protective uncle to his nieces.

Borden is Tema's husband, an English actor who performs alongside her in Dallas. He is supportive but somewhat detached from the deep, spiritual reality of Tema's Choctaw heritage, often seeking logical explanations for her visions.

Father Renoir is a French Catholic missionary priest living with the Choctaw in the 18th century. He documents the history of the tribe for his superiors but struggles with the corruption of his own colonizing culture and his growing affection for the Choctaw people, particularly Neshoba.

Vic is a dangerous mafia associate involved with the Choctaw casino. He and his brother press Carl Tonica to recover the massive sum of money that Chief McAlester stole from them, bringing a lethal outside threat to the tribal community.