An unnamed narrator, writing from a future era in which humanity has been replaced by a new species, introduces the story of Michel Djerzinski, a molecular biologist who lived in Western Europe during the latter half of the twentieth century, a miserable age in which love, tenderness, and human fellowship had largely disappeared. The narrator defines "metaphysical mutations" as rare, radical transformations in societal values and identifies Djerzinski as one of the most clear-sighted engineers of the third such mutation.
In late June 1998, Djerzinski, a 40-year-old department head at a research facility in Palaiseau, holds a perfunctory farewell party as he begins an indefinite sabbatical. He returns to his Paris apartment, where he has lived alone for 10 years. His pet canary, his only companion, has died. When his supervisor Desplechin asks what he plans to do, Michel answers: "Think." He spends weeks barely moving, weeping over a school photograph of a happy child he can no longer recognize.
The narrator traces the family history of Michel and his half brother Bruno. Their mother, Janine Ceccaldi, daughter of a man born to illiterate Corsican peasants who rose through France's school system, proves extraordinarily intelligent and sexually precocious. She leaves Algeria for Paris to study medicine and in 1952 meets Serge Clément, an ambitious plastic surgeon who becomes Bruno's father. Bruno is born in 1956, but both parents find child-rearing incompatible with personal freedom and send him to live with his maternal grandparents in Algeria. Janine becomes pregnant by Marc Djerzinski, a withdrawn documentary filmmaker, and Michel is born in 1958. When Marc returns from China in 1961, he finds Michel crawling in filth and takes him to his own mother in the rural Yonne region. Janine departs for America; Marc later travels to Tibet and is never heard from again.
Michel grows up peacefully with his grandmother, first in Charny and then in Crécy-en-Brie near Paris, developing a passion for science and a horror of nature's cruelty. Bruno's childhood is shaped by humiliation and loss. His grandmother, his sole caretaker, slowly declines and dies in 1967. Bruno, now 11, overhears his estranged parents deciding his future and is enrolled at a boarding school in Meaux, where he endures savage bullying while spending hollow Sundays with his father, who cannot connect with him.
In September 1970, Michel meets Annabelle Wilkening in German class. She comes from a stable family and recognizes she has found true love. They grow close, but Michel, deprived of maternal contact in infancy, proves incapable of physical intimacy. After the
baccalauréat (the French school-leaving exam), Bruno, Michel, and Annabelle travel to a commune in Haute-Provence, where the founder's son David di Meola seduces Annabelle. One night she breaks away from David and asks Michel to dance; he declines, and she returns to David's arms. Michel leaves the next morning. Annabelle discovers she is pregnant, has an abortion, and writes Michel a 40-page love letter. He never responds. In November, Michel's grandmother dies. Outside the house in Crécy, Annabelle stands in the rain, knowing she could ring the doorbell. She goes home instead. They will not see each other for almost 25 years.
Part Two opens in the summer of 1998. Bruno, 42, divorced, and sexually obsessed, drives to the Lieu du Changement, a campsite south of Cholet whose utopian origins have given way to New Age workshops and corporate team-building courses. After a week of failure, he meets Christiane, a 40-year-old biology teacher from Noyon, in a late-night encounter at the outdoor Jacuzzi, and they begin a tender relationship.
Over a drunken evening at Michel's apartment, Bruno confesses his life history: compulsive eating, the death of a girlfriend who jumped from her apartment window, a loveless marriage to a woman named Anne, and a breakdown after he became fixated on a teenage student at the
lycée (upper secondary school) where he taught. He was hospitalized, divorced, and settled into bureaucratic work at the Ministry of Education.
Michel intuits during a fast that perfect DNA replication is impossible while the molecule remains a double helix and that genetic information would need to be on a compact topological structure. These notes form the basis of his most important work. Bruno and Christiane deepen their relationship at couples' clubs and the nudist colony at Cap d'Agde on the French Mediterranean coast. Bruno tells Christiane he is happy and wants to live with her. For the first time, something seems feasible.
Michel reunites with Annabelle when he returns to Crécy for his grandmother's grave relocation. They begin seeing each other, and Annabelle tells him about years of unhappy relationships. They sleep together; Michel feels little sexual pleasure but deep comfort. Their reunion is gentle but shadowed by an approaching finality.
Christiane collapses and is diagnosed with spinal necrosis that leaves her permanently paralyzed. When she suggests Bruno need not devote his life to her, he hesitates too long. Alone in Noyon, Christiane throws herself down the stairs and dies. Bruno admits himself to a psychiatric clinic. The brothers travel separately to the village of Saorge above Nice, where their mother, Janine (now going by "Jane"), is dying among aging hippies. Bruno, temporarily released and on lithium, alternates between wild rants and cruel taunts at her bedside. Jane dies, and they bury her that afternoon. They part at the train station and never see each other again.
Michel tells Annabelle he is moving to the Galway Center for Genetic Research in Ireland to discover the general conditions for mutation stability. Devastated, she asks him to give her a child. She becomes pregnant but is diagnosed with uterine cancer. After surgery, metastases appear. One night she takes a deliberate overdose, leaving a note: "I prefer to die surrounded by those I love." She dies two days later. Michel hears the bells at the train crossing and remembers how Annabelle met him at the station when he was 15.
Michel moves to Clifden on the Irish Atlantic coast, where he spends months in solitary reflection. According to Frédéric Hubczejak, his future annotator, this is when his theory crystallizes. Over the following years he publishes landmark papers, including
The Topology of Meiosis, establishing that all sexually reproducing species are mortal. In Dublin he encounters the Book of Kells, a lavishly illuminated medieval manuscript whose interweaving forms profoundly influence his thinking. In
Meditations on Interweaving, he writes that "love binds, and it binds forever."
On 27 March 2009, Michel mails his 80-page synthesis to the Académie des Sciences and the journal
Nature. His car is found near Aughrus Point, the westernmost point of Europe. The narrator states: "We now believe that Michel Djerzinski went into the sea."
The epilogue recounts the aftermath. Researchers confirm that any genetic code can be encoded in a structurally stable form, making immortality possible. Hubczejak, a young biochemistry student at Cambridge, champions Michel's radical proposal: that humanity must give way to a new asexual, immortal species. On 27 March 2029, the first member of the new species is created. Fifty years later, humanity is going extinct peaceably. The narrator salutes the old species as a "vile, unhappy race" that "never quite abandoned its belief in love" and proved capable of envisioning its own succession. The book is dedicated to mankind.