Chona's gentle and fretful husband, Moshe is a central figure in the novel. He dotes on Chona and is deeply affected by her health and activism. Moshe is also known for his mercy and community-building efforts, opening his theater to Black patrons and performers and welcoming Nate's nephew into their home.

A lonely, bright, and brave young boy, Dodo is deaf and becomes a pivotal character in the novel. He is taken in by Chona and Moshe, who recognize his intelligence and courage, despite the town's ableist assumptions. Dodo's struggle for freedom and justice drives much of the plot and themes, especially his life-changing relationships across different cultures.

Dodo's dependable and fiercely protective uncle, Nate is one of Moshe's closest friends and allies. He is a secretive man with a mysterious past, but his commitment to his nephew and the broader community plays a significant role in the novel. He is instrumental in advancing the plot and themes of justice and intercultural solidarity.

The self-righteous and prejudiced antagonist of Heaven & Earth Grocery Store, Doc Roberts is characterized by his racist and antisemitic views, which he attempts to justify with religious and patriotic rhetoric. His malicious actions towards Chona and Dodo drive much of the conflict in the storyline, creating a need for community solidarity and justice.