Teresita is the illegitimate daughter of Tomás Urrea and Cayetana Chávez. Abandoned by her mother and raised in poverty by her abusive aunt, she possesses distinct spiritual and healing gifts. Growing up on her father's ranches in Sinaloa and Sonora, she learns traditional Indigenous medicine while observing Catholic practices. She is strong-willed, fiercely protective of Indigenous people, and deeply conflicted by the heavy responsibilities her abilities place upon her.

Tomás is the wealthy, powerful patron of ranches in Sinaloa and Cabora. He maintains a refined public image but secretly yearns for the rugged, adventurous lifestyle of the countryside. He raises bees, preferring their organized society to the artificial manners of high-class city life. He harbors guilt over his infidelities while striving to protect his properties and workers from political instability.

Huila is an elderly curandera, midwife, and the respected head of Tomás's household staff. She commands immense authority among the Indigenous workers due to her mystical abilities and deep knowledge of medicinal flora. She functions as a vital bridge connecting Catholic doctrine with Indigenous spiritual traditions on the ranch.

Enríquez is a military officer enforcing the policies of the Díaz government. His duties frequently require him to suppress Indigenous uprisings and enforce land seizures. He faces a profound internal conflict between his orders from the state and his personal respect for Tomás Urrea.

Cruz Chávez is the self-proclaimed Pope of Mexico and the militant leader of the community of Tomóchic. He harbors a deep, righteous anger against the Mexican government for its atrocities against Indigenous populations. He believes in holy war and uses his devotion to justify violent rebellion.

Aguirre is an educated engineer and the political conscience of the Urrea circle. He openly criticizes the corrupt Porfirio Díaz regime and advocates for a united Mexican revolution centered on Indigenous land rights. He publishes anti-government newspapers and works to raise awareness of systemic abuses.

Buenaventura is the illegitimate son of Tomás who initially works as a ranch hand to earn a rifle. He struggles with his father's overt rejection and hostility. He grows deeply jealous of the preferential treatment Teresita receives and harbors resentment over his marginalized status within the family.

Loreto is Tomás's cousin and legal wife. She prefers the refined, upper-class lifestyle of the city of Alamos over the dirt and chaos of ranch life. She maintains a dignified household but refuses to tolerate the public embarrassment of her husband's infidelities, leading to their permanent separation.

Gabriela is the young daughter of a restaurant proprietor who captures Tomás's affection. She embraces the rural life at Cabora and quickly establishes a loving, devoted relationship with Tomás. She acts as a willing companion to Teresita and adapts easily to the unconventional nature of the Urrea household.

Cayetana is a young woman who gives birth to Tomás's daughter. She finds the demands of motherhood exhausting and resents the physical toll of raising a child. After recognizing the severed head of a bandit who once showed her kindness, she abandons her toddler and flees the ranch.

Tía is Cayetana's sister who reluctantly takes in Teresita. She is an exhausted, impoverished mother who deeply resents the burden of an extra mouth to feed. She subjects Teresita to physical and emotional abuse before eventually abandoning the ranch to follow a child messiah.

Segundo is the loyal and capable foreman of Tomás's ranch properties. He manages the Indigenous workers, organizes the massive relocation to Sonora, and acts as a trusted lieutenant in times of crisis. He takes an early liking to Buenaventura and helps integrate him into the ranch's operations.

Niño Chepito is a young messianic figure who gathers a large following of Indigenous people. He claims to be God and preaches a violent theology predicting the deaths of white men. His movement captures the desperate religious fervor of the displaced populations.

Manuelito is a Sonoran hechicero and healer who wears a combination of Catholic and Indigenous spiritual symbols. He acts as a secondary mentor to Teresita, teaching her the medicinal properties of thousands of regional plants and advising her on finding spiritual balance.

Cantúa is the proprietor of a local restaurant and the father of Gabriela. He views Tomás's romantic interest in his daughter as a profitable opportunity to secure her future and finance his own return to his family on the coast.

Padre Gastélum is a Catholic priest who views Teresita's spiritual practices and growing influence with intense hostility. He acts as an informant for the government and preaches sermons condemning Teresita as a demonic presence.

Juan Francisco is the oldest legitimate son of Tomás and Loreto. He harbors resentment toward his father's illegitimate children but is ultimately trusted by his father to help defend and run the ranch during military threats.

Millán is a young man at Cabora who assaults Teresita in her sacred grove and leaves her for dead. His brutal actions precipitate the central spiritual transformation in Teresita's life.

Don Teófano is an older ranch worker who supervises Teresita during her exile to the Aquihuiquichi satellite property. He provides a stabilizing, protective presence while she first begins delivering babies and treating livestock.

José is a follower of Cruz Chávez who suffers from a large tumor on his neck. He acts as the primary test case for the Tigers to determine if Teresita's miraculous healing abilities are genuine.