Amy is a quiet, observant six-year-old girl who becomes the target of a covert government experiment known as Project NOAH. She possesses a mysterious, calming influence over animals and humans alike. Though vulnerable, her unique biology and unexplainable presence make her the focal point of the military's disastrous scientific ambitions.

Wolgast is a 44-year-old FBI agent weighed down by the loss of his infant daughter and his subsequent divorce. He buries himself in his work for Project NOAH, utilizing his natural empathy to convince inmates to sign their lives away. When ordered to retrieve a young girl for the project, his dormant paternal instincts force him to abandon his orders and go on the run.

A nun originally from Sierra Leone, Lacey carries the psychic weight of a traumatic childhood marked by civil war. She experiences profound empathy, often overwhelmed by the loneliness she senses in others, and believes she hears the voice of God. She forms an immediate, powerful attachment to Amy and views herself as the girl's appointed guardian.

A capable but brooding young man living in a fortified compound a century after the virus outbreak. He struggles to find his place in the shadow of his legendary father and capable older brother. Despite his quiet insecurities, he acts as a natural leader and feels a restless drive to explore beyond the Colony's walls.

Peter's older brother and the expected heir to their father's reputation. Outwardly strong and dependable, Theo is respected by the community but secretly harbors a desire for a peaceful, domestic existence. His disappearance during a scouting mission deeply affects the remaining survivors.

Known as "Blades," she is a fiercely capable warrior raised by a mysterious military figure after a tragedy orphaned her at a young age. She is pragmatic and highly trained in weaponry, hiding her true feelings behind a tough, uncompromising exterior. She prioritizes duty and survival above all else.

A former death row inmate with a horrific history of childhood abuse who becomes one of the original Twelve test subjects. Transformed by the virus, he possesses immense physical power and psychic abilities, which he uses to invade the minds of survivors and demand human sacrifices.

A Harvard professor of molecular biology whose grief over his wife's illness drives him to seek a cure for aging. His expedition discovers a terrifying virus that he utilizes as the foundation for Project NOAH, setting apocalyptic events into motion in his desperate bid to defeat death.

A gentle, easily confused 32-year-old death row inmate accused of murdering a woman who had tried to help him. He agrees to join the mysterious medical trial in hopes of buying enough time to understand his own past. His inherent mildness contrasts sharply with the monstrous fate intended for him.

A highly intelligent engineer responsible for maintaining the electrical grid that protects the Colony. He is resourceful and deeply curious about pre-apocalyptic technology, using his great-grandfather's old logbooks to monitor mysterious radio frequencies that hint at a wider world.

Michael's sister and a compassionate nurse who bears witness to the physical and emotional suffering within the Colony. She is deeply empathetic, believing her purpose is to help others shoulder their grief, and harbors a quiet, enduring affection for Peter Jaxon.

A steadfast, reliable member of the Colony's survival teams. Practical and resilient, Hollis proves fiercely loyal to his friends during dangerous excursions beyond the safety of the walls, finding comfort in their shared mission.

The daughter of prominent Colony leaders caught in a complicated domestic situation. Forced to retire from her duties, she struggles with her lingering attachment to the missing Theo Jaxon while navigating a tense marriage to Galen.

Mausami's husband, a man who initially attempts to be a supportive partner but grows bitter due to her clear indifference. His jealousy over Theo Jaxon and his poor eyesight make him defensive and prone to erratic behavior.

A cynical, ruthless operative running the daily security of the NOAH facility. Viewing human history as an endless war, he sees the terrifying test subjects as a natural evolution of violence and falls under the psychic influence of the creatures he is meant to guard.

A former prison inmate who takes a cleaning job at the NOAH facility as a condition of his release. Heavily medicated to suppress memories of his dark past, his fragile mind quickly unravels as the psychic presence of the test subjects invades his thoughts.

Known to the Colony as Auntie, she is the elderly matriarch and record-keeper of the community. Having survived the initial outbreak, she dedicates her long life to chronicling history and preserving memories of the old world for the younger generations.

A respected leader within the Colony and Mausami's father. He battles severe sleepwalking episodes and terrifying, intrusive dreams, making him highly vulnerable to the psychic influence of the virals gathering outside the walls.

The smiling, ostensibly hospitable leader of a survivor community living in an old prison. He presents a facade of safety and comfort, but hides a grim, desperate arrangement required to keep his people safe from the viral threat.

A blue-eyed man at the Haven who serves as a willing familiar to the viral threat. He orchestrates dark bargains to maintain the safety of his community, displaying a disturbing eagerness to sacrifice other humans.

A mysterious military figure who arrived at the Colony wearing a necklace of viral teeth. He took in the orphaned Alicia and subjected her to brutal, unforgiving training, initiating her into a larger, hidden military order.

The grim, highly disciplined leader of a military outpost in Texas. He commands a unit of soldiers sworn to die for humanity's survival, maintaining strict rules and a cynical outlook regarding the outside world.

An amiable military leader running a small but well-fortified garrison. Unlike his rigid counterpart, Greer is observant and thoughtful, recognizing Amy's unique importance based on childhood visions he experienced.

A former friend of Jonas Lear who became the very first test subject for the NOAH virus. Mutated into a terrifying, hairless creature with psychic abilities, he initiates the facility's downfall through mental manipulation.

A kind but deeply depressed suburban mother who attempts to help a homeless man find work. Her severe mental health struggles lead to a tragic incident in her family's swimming pool, profoundly altering Carter's life.

A medical doctor and Brad Wolgast's ex-wife. The devastating loss of their infant daughter caused irreparable damage to their marriage, leading her to seek a new life and start another family.

Peter and Theo's late father, an adventurous and revered figure in the Colony. He bravely scouted the dangerous outside world on horseback, leaving behind a legacy that heavily influences the paths of his sons.