Tupac is a young musician and poet who compares himself to a rose growing through a crack in the pavement. He transitions from a disenfranchised inner-city youth to a highly recognizable music figure. He uses his art to highlight social issues and the resilience of Black Americans, writing verse to process his environment.

Afeni is Tupac's mother and a member of the Black Panther Party. She acts as her own legal counsel to defend herself against serious charges in court. She later battles drug addiction but successfully works to gain Tupac admission to the Baltimore School of the Arts.

Leila is a singer and dancer who recognizes Tupac's artistic potential early on. She steps into the role of his first manager despite having no prior experience in the field. She utilizes her connections to introduce him to established industry professionals.

Atron is a music manager. He secures Tupac an early gig working as a roadie and dancer for the rap group Digital Underground.

Dan is the Vice President of the United States. He publicly condemns Tupac's record as having no place in society, an action that unintentionally increases the album's visibility and sales.

The Notorious BIG is a prominent New York rapper. He is present at a recording studio during a violent incident involving Tupac, sparking tension between the artists and contributing to an escalating coastal feud.

Sean is a music producer operating in the East Coast rap scene. Tupac suspects him of organizing a violent robbery.

James is a music manager active in the East Coast rap scene. He is one of the men Tupac suspects of coordinating an attack against him.

Suge runs Death Row Records. He secures Tupac's release from jail by offering him a recording contract with his label, intertwining their business interests.