Dream is one of the Endless, immortal beings who embody natural forces of the universe. He governs the domain of sleep, nightmares, and imagination. After suffering decades of captivity at the hands of human occultists, he escapes and must track down his stolen tools of office. He approaches his duties with intense seriousness and struggles to relate to humanity on an emotional level.

Death is Dream's older sister and his closest confidante. She greets every human being at the end of their life to guide them to the other side. Unlike traditional depictions of the grim reaper, she dresses like a contemporary young woman and approaches her somber job with immense compassion, patience, and good humor.

Desire is a genderfluid member of the Endless who personifies human want and craving. They view humans merely as toys to be twisted and manipulated. They hold a specific, enduring grudge against Dream and actively look for ways to undermine him or cause him pain.

Rose is a young, independent woman searching for her lost younger brother, Jed. During her search, she stays in an eccentric rooming house and travels across the country. She slowly learns she has a dangerous, natural connection to the world of sleep.

Barbie is a young woman who recently went through a bad breakup and moved to an apartment in New York. She suffers from a complete inability to sleep deeply or imagine things, having lost her childhood connection to a vast fantasy world. She slowly begins to recover her memories of the past.

Wanda is a transgender woman who lives in the same apartment building as Barbie. She left her unsupportive family behind in the Midwest to build a genuine life in New York. She provides emotional support to Barbie and faces the supernatural disruptions in their building with practical bravery.

Roderick Burgess is a wealthy human occultist and the leader of a secret mystical order. He attempts to capture Death to demand immortality, but accidentally traps her younger brother instead. He spends the rest of his life trying to negotiate a deal with his silent prisoner.

Alex is Roderick's son. He inherits his father's estate, his occult organization, and his supernatural prisoner. Fearful of the consequences of setting the entity free, Alex maintains the glass prison into his old age.

Also known as Doctor Destiny, John Dee is a supervillain whose mind has completely deteriorated. He inherits a powerful ruby amulet and escapes from his asylum to inflict widespread madness on the world. He takes over a 24-hour diner to test his reality-warping powers on the patrons inside.

Lucifer Morningstar is a fallen angel and the ruler of Hell. He governs the underworld as part of a triumvirate. He grows tired of the millions of demons and damned souls who populate his domain and begins to question the grand design that placed him in this role.

The Corinthian is a rogue nightmare who escaped into the waking world during his creator's imprisonment. He operates as an elusive serial killer, attending a convention for murderers and viewing himself as a dark artist of human suffering.

Despair is the personification of human misery and hopelessness. She observes the waking world through mirrors, watching people when they hit their lowest emotional points. She frequently aligns herself with her twin sibling Desire in family disputes.

Destiny is the oldest of the Endless siblings. He carries a heavy book chained to his wrist that contains the past, present, and future of all existence. He is a passive figure who only observes and facilitates the events written in his pages.

Delirium is the youngest of the Endless family. Her physical appearance constantly shifts, and her thoughts are incredibly scattered. She often makes nonsensical statements or follows conversational threads that no one else can see.

Destruction is the missing member of the Endless, frequently referred to by the others simply as "the Prodigal." He abandoned his duties and walked away from his family long ago, creating a permanent fracture in their dynamic.

Jed is Rose's younger brother. After running away from home years ago, he was taken in by a foster family that keeps him imprisoned for the monthly government checks. To survive his terrible waking life, he escapes into an elaborate, persistent sleep environment.

Miranda is Rose and Jed's mother. She was adopted as a child and travels to Europe to finally meet her biological mother, Unity Kincaid. She relies heavily on Rose to help repair their fractured family.

Unity is a wealthy woman from England who was afflicted by a worldwide sleeping sickness in 1916. She slept through her entire youth and adulthood, waking up only when the sickness finally broke in the late 1980s. She seeks to reconnect with the family she lost during her long slumber.

Gilbert is a polite, heavyset older gentleman who lives in the same rooming house as Rose. He dresses in old-fashioned clothing and carries a sword cane. He takes an immediate, grandfatherly interest in Rose and accompanies her on a road trip to find her brother.

Hal is the landlord of a large, eccentric house where several characters rent rooms. He performs as a drag queen at a local club under the name Dolly. He acts as the social anchor for the tenants living under his roof.

Hazel is a young woman living in the New York apartment building. She works as a chef and is currently dealing with an unexpected pregnancy following a brief encounter with a coworker. She worries about how her girlfriend will react to the news.

Foxglove is Hazel's girlfriend and lives in the same building. She is a musician trying to build her career. She carries lingering trauma from a previous abusive relationship that ended tragically.

Thessaly is a quiet, unassuming woman who lives in Barbie and Wanda's building. Beneath her plain exterior, she possesses ancient, lethal supernatural knowledge and does not hesitate to use extreme violence to protect herself and exact revenge on her attackers.

John is a cynical, tough-talking British occultist and con man. He crosses paths with supernatural forces regularly and ends up with a pouch of magical sand that belongs to the lord of sleep. He reluctantly agrees to help track the stolen item down.

Nada is the ancient queen of a lost glass city. Millennia ago, she fell deeply in love with a supernatural entity, an act that resulted in the destruction of her civilization. She chooses to suffer eternal punishment rather than compromise her beliefs.

Calliope is a muse from Greek mythology. She is bound by magical laws that force her to serve whoever holds her captive, currently suffering abuse at the hands of an arrogant author who uses her to gain inspiration for his books. She is desperate for rescue.

Orpheus is a mythological Greek figure and a legendary musician. He travels to the underworld to save his beloved wife. After suffering a terrible tragedy, he lives out an immortal, bodiless existence while holding onto immense grief and anger.

Johanna is an 18th-century adventurer and occultist. She takes on dangerous supernatural jobs for high-paying clients, crossing paths with political figures like Robespierre. She works as an agent to smuggle a highly unusual artifact out of a war zone.

Hob is a regular human man who casually states in a tavern that he simply refuses to die. Unbeknownst to him, supernatural forces overhear and grant his wish. He lives through centuries of human history, experiencing immense wealth, terrible poverty, and profound societal changes.

Lucien is the chief librarian of a massive library containing every book ever dreamed of. He acts as the steward of the castle, trying to hold the crumbling domain together while his leader is imprisoned on Earth.

Matthew is a raven who serves as an emissary and scout. He was formerly a human being but transitioned into a bird after his death. He flies into different realms to gather intelligence and provide commentary.