Maggie is a 20-year-old Dinétah monster hunter who lives in self-imposed isolation. Gifted with supernatural clan powers, she is highly sought after by local communities to deal with the deadly creatures roaming the post-flood Sixth World. She harbors deep emotional scars and self-doubt following the sudden abandonment of her former mentor.

Kai is an attractive, sharply dressed young man training to be a medicine man. Armed with a deep knowledge of monsters and claiming to possess healing clan powers, he contrasts sharply with Maggie's rugged isolation. His diplomatic skills and calm demeanor make him a valuable addition to their monster-hunting efforts.

Neizghání is an immortal, winged Dinétah Holy Person and a legendary monsterslayer. He previously took Maggie under his wing to train her in harnessing her clan powers. To the Diné people, he is a celebrated hero, but his harsh teachings have left deep wounds in his former apprentice.

Grandpa Tah is an elderly, highly respected monster expert living in Dinétah. Though not biologically related to Maggie, he treats her like a daughter and provides one of her only tethers to a sense of community. He actively tries to help her reconnect with the world by pairing her up with his grandson.

Ma'ii, also known as Coyote, is a powerful Dinétah trickster god who takes a distinct interest in Maggie's life. He blends a casual, friendly demeanor with a dangerous, manipulative edge. He visits Maggie to tease her about her past and pressure her into running supernatural errands.

Grace is a tough, pragmatic bar owner who serves as the head of a close-knit family. She harbors a deep hatred for the local lawmen following the death of her husband during the Big Water. Though she maintains a hard exterior, she possesses strong maternal instincts toward those she respects.

Chris Tsosie, widely known as Longarm, is an aggressive member of the Citizen's Watch and Guard in Tse Bonito. He harbors a deep, persistent grudge against Maggie and uses his position of authority to bully and intimidate those around him.

Rissa is Grace Goodacre's daughter, a capable and observant young woman who helps manage the family's business and defense. She approaches the dangerous post-flood world with a pragmatic bravery and an awareness of the area's supernatural threats.

Clive is Grace Goodacre's son, stepping up to defend his family against the constant threats of the Sixth World. He is surprisingly well-versed in both combat and fashion, wielding a flamethrower in battle while also understanding the high-society expectations of supernatural nightclubs.

Hastiin is the leader of the Thirsty Boys, a group of mercenaries patrolling the roads in the Sixth World. He uses his authority to control the flow of travelers and gather information on the strange occurrences in the valley.

Mósí is an immortal, feline-like divine being who operates the fighting ring at the Shalimar. Sly and secretive, she treats human interactions like a game, toying with her targets and hoarding valuable information.