Abe is an author and college instructor who comes from a Jewish family in New York. Early in his adult life, he works for his father's business but transitions to writing full-time after receiving encouragement from his partner. He regards his creative work as central to his existence, eventually publishing multiple novels and teaching fiction classes. As his wife undergoes cancer treatment, he commits himself to recording their shared history on paper.

Jane is a dedicated visual artist whose creative output includes drawings, watercolor paintings, and wax sculptures. She traces her Iraqi heritage through her late mother, who immigrated from Baghdad and died of cervical cancer when Jane was a child. Her artistic drive defines her early adult years until she experiences severe postpartum depression. Following her own cancer diagnosis, she begins to reevaluate the balance between her artistic ambition and her family commitments.

Max is the adult son of Abe and Jane. He intentionally builds a life completely separate from his parents' artistic ideals, choosing to work on the business side of the art world rather than creating art himself. He actively avoids long-term commitments, spending his time attending yoga classes and keeping his family at a comfortable distance.

Alice is a college student studying creative writing. She wears Chanel No. 5 perfume gifted by her mother and relies heavily on external validation. After reading Abe's published fiction, she develops a profound infatuation with him, frequently visiting his office under the guise of discussing her craft. Her attachment to her professor blurs the line between professional admiration and romantic pursuit.

Bubbe is Abe's mother and the matriarch of his family. She provides essential stability for her son's household, stepping in as Max's primary caretaker when Jane is unable to fulfill the role. She is welcoming to her daughter-in-law, immediately gifting Jane a blue shawl that becomes a cherished possession.

Jaclyn is an independent woman who captures Max's attention in the city. Initially seeming indifferent to his advances, she eventually agrees to go on a date with him. Her presence forces Max to confront his deep-seated fears regarding intimacy and long-term attachment.

David is Abe's brother. He forms an immediate bond with Jane, trusting her enough to confide his sexual orientation to her before telling anyone else in his family. He remains a supportive background presence as his brother builds a life with Jane.

Bea is a visual artist and Jane's best friend. She provides Jane with vital companionship and artistic camaraderie as she establishes her career in New York City.

Margaux is Alice's roommate in the city. She silently observes Alice's changing habits and recognizes her growing infatuation with her college professor.

Todd is a friend of Max. He attempts to offer sympathy by sharing his own family experiences, though his efforts sometimes miss the mark with his emotionally distant friend.

Bernie is a medical professional hired to assist with Jane's care. She manages Jane's physical needs so that Abe and Jane can focus on spending their remaining time together.