Volpone is a wealthy, unmarried Venetian gentleman with an intense love for gold and worldly pleasures. Without a natural heir, he pretends to be on the brink of death to extort extravagant gifts from greedy locals who hope to inherit his vast estate. He delights in the theatricality of his cons, treating the deception of his greedy suitors as a highly entertaining intellectual exercise.

Mosca is Volpone's parasitic underling and chief accomplice. Possessing a quick wit and a talent for flattery, he effortlessly adapts his persona to manipulate each of Volpone's suitors. He handles the logistics of the inheritance con, acting as the primary point of contact for the eager visitors while his master feigns illness in bed.

Voltore is an ambitious Venetian lawyer whose name translates to vulture. He uses his rhetorical skills and professional standing to pursue Volpone's fortune, gladly setting aside legal ethics in exchange for the promise of immense wealth.

Corbaccio is an extremely elderly, hard-of-hearing gentleman who hopes to outlive Volpone and claim his estate. Despite his own advanced age and frail health, his greed drives him to consider disinheriting his own son just to improve his standing in Volpone's fake will.

Corvino is an insecure, highly jealous Venetian merchant. He keeps his beautiful wife, Celia, locked away at home due to his extreme paranoia about her fidelity. However, his desperate desire for wealth easily overrides his personal convictions when the inheritance is on the line.

Sir Politic is an English knight traveling in Venice. He considers himself a sophisticated statesman and observant traveler, but he is incredibly gullible and superstitious. He constantly devises absurd business schemes, like using onions to detect the plague, while remaining completely unaware of how foolish he appears to others.

Lady Would-Be is Sir Politic's vain, talkative wife who relocated to Venice to keep up with current fashions. She considers herself highly educated and peppers her lengthy, one-sided conversations with literary allusions, exhausting anyone who has to listen to her.

Celia is Corvino's beautiful and deeply pious wife. Kept in strict seclusion by her jealous husband, she serves as a symbol of virtue in a city filled with vice. Her striking appearance unfortunately captures Volpone's lust, drawing her into his web of deceit.

Bonario is Corbaccio's honorable, good-natured son. He maintains a solid reputation for honesty and fairness, making him an outlier in corrupt Venice. His straightforward nature puts him directly in the crosshairs of Mosca's malicious plots regarding his father's estate.

Peregrine is a rational English traveler who serves as a foil to the absurd Sir Politic. He quickly recognizes the knight's foolishness and amuses himself by feeding Sir Politic ridiculous rumors, observing the man's gullible reactions with sarcastic delight.

Nano is a dwarf who works as one of Volpone's household fools. He participates in crude, satirical performances to entertain his master, mocking intellectual and religious concepts for Volpone's amusement.

Androgino is an intersex person employed as a fool in Volpone's household. Along with Nano and Castrone, Androgino provides crude entertainment for Volpone, performing comedic plays written by Mosca.

Castrone is a eunuch who serves as one of Volpone's three fools. He contributes to the household's bizarre atmosphere by participating in the satirical songs and skits designed to keep Volpone amused between visitors.