Daisy is a striking, talented young woman born to wealthy, dismissive parents in Los Angeles. She spends her early teens sneaking into Hollywood clubs, quickly becoming a popular fixture among musicians and artists. Though men often view her as a muse, she harbors a strong desire to create her own music and establish an independent artistic identity.

Billy is the lead singer and primary songwriter for the Dunne Brothers, which later evolves into The Six. Driven by a fear of repeating his father's mistakes, he throws himself entirely into his music career. He battles severe substance abuse issues as his band gains fame, creating a constant struggle between his chaotic rock-and-roll lifestyle and his desire to be a stable family man.

Camila is a confident and determined young woman who falls in love with Billy and supports his passion for music. When the band moves to Los Angeles, she follows them to help build a life with Billy. She provides a grounding influence against the chaos of the music industry and holds a clear, unshakeable vision for her family's future.

Graham is Billy's younger brother and a founding member of the Dunne Brothers band. He shares his brother's deep love for music but approaches life with more emotional stability, avoiding the severe addiction issues that plague Billy. He provides unwavering support for his brother while quietly harboring strong romantic feelings for the band's keyboardist.

Teddy is an experienced music producer who signs The Six and, separately, Daisy Jones. He possesses a deep understanding of how to pull the best possible work out of his artists, acting as both a musical guide and a father figure. He plays a crucial role in managing Billy's sobriety and guiding Daisy toward finding her authentic voice.

Eddie is the younger brother of Pete Loving and the rhythm guitarist for The Six. He steps into the band eagerly but quickly finds himself frustrated by the group's internal dynamics. As the band's fame grows, he increasingly resents Billy's strict leadership style and his own lack of creative input.

Karen is a highly skilled keyboardist who leaves her first band because she wants to be respected purely as a musician, not objectified by her bandmates. She joins the Dunne Brothers, renames them The Six, and establishes herself as a crucial musical force. She values her independence and pushes against the male-dominated expectations of the 1970s music industry.

Pete is a childhood friend of the Dunne brothers and the steady bass player for The Six. Unlike his bandmates, he lacks a driving thirst for global fame and power, viewing the band primarily as a way to play rock music. His long-term goals revolve around settling down with his girlfriend rather than embracing the chaotic rock-star lifestyle.

Warren is an easy-going childhood friend of the Dunne brothers who plays drums for The Six. He thoroughly enjoys the perks of rising fame and consistently encourages his bandmates to stop taking the music industry so seriously. He provides a rational, drama-free presence amidst the band's frequent creative and interpersonal clashes.

Rod is an experienced music manager who convinces The Six to relocate to Los Angeles. He helps secure their recording deal with Runner Records and remains a steadying force as the band experiences sudden fame. He genuinely cares for the musicians under his guidance, regularly stepping in to handle logistical crises and personal emergencies.

Simone is a rising disco star and Daisy's first true friend in Los Angeles. She provides the teenage Daisy with a safe place to live and insists she finish high school, acting as a rare voice of reason in an industry full of enablers. Even as her own music career experiences ups and downs, she remains deeply protective of Daisy.

Julia is Billy and Camila's eldest daughter. Her impending birth serves as the catalyst for Billy's decision to finally confront his substance abuse issues. She represents the stable, family-oriented life that Billy strives to maintain in the face of his rock-and-roll career.

Chuck is a talented rhythm guitarist who helps the Dunne brothers get their start playing dive bars in Pennsylvania. His tenure with the band is cut short when he is drafted into the Vietnam War, leading to his replacement by Eddie Loving.

Hank is a music manager and romantic partner to Daisy before she joins The Six. He attempts to control her career and keep her reliant on him by enabling her drug use, representing the predatory side of the music industry that Daisy fights to escape.