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Content Warning: This section of the guide includes discussion of illness, mental illness, emotional abuse, and gender discrimination.
Lilly R. began having night sweats, joint pain, dry skin, hair loss, and an intolerance to red wine at 39, followed by years of insomnia and a diagnosis of functional depression. At 43, she rapidly gained 10 pounds, and her cholesterol, triglycerides, and blood glucose became concerning. Her gynecologist dismissed her concerns, saying that “Latina women” do not enter perimenopause until 49. When Lilly pushed for hormone testing, she was told that everything was normal. A menopause specialist later prescribed hormone therapy. Within six months, Lilly felt like herself again. She reflects that menopause is rarely discussed in the Hispanic community and that clinicians must stop dismissing women’s experiences.
Haver positions perimenopause as a time to protect long-term health rather than simply endure symptoms. Research is sparse and often extrapolated from non-perimenopausal models, and medical training has historically emphasized treating symptoms in isolation rather than the underlying hormonal instability. Treatment is individualized and often iterative.
Hormones act as chemical messengers; when levels fluctuate, cellular communication falters. A proposed term, PET hormones (progesterone, estrogen, testosterone), better reflects broader use than MHT. Estradiol is the most potent estrogen and swings widely in perimenopause, estrone dominates post-menopause, and estriol is largely a pregnancy hormone. Progesterone supports sleep and mood but wanes with irregular ovulation, and androgens like testosterone affect sexual function, energy, and mood.
Perimenopause begins in the brain: Erratic estradiol destabilizes the feedback loop between the brain and the ovaries, causing dramatic mood swings. Low-dose estradiol can steady signaling and reduce mood swings without fully suppressing ovulation. In women with a uterus, progesterone is added to protect the endometrium (the lining of the uterus). Two approaches exist: suppress and replace (higher-dose contraceptives) or support (low-dose therapy to stabilize fluctuations). For other symptoms, progesterone alone may improve luteal-phase sleep disruption; transdermal estradiol can treat perimenopausal depression.
Absolute MHT contraindications—or factors that indicate certain treatment should not be used—include hormone-sensitive cancer, undiagnosed bleeding, active thromboembolic disease, pregnancy, severe liver disease, and hypersensitivity. However, there are common misconceptions in the medical community that wrongly exclude many from MHT treatments. A history of endometriosis or adenomyosis, a family history of heart and liver disease or breast cancer, and concerns over clotting shouldn’t prevent treatment. For example, non-oral estrogen does not raise clotting risk above baseline. Contraceptive therapy suppresses ovulation using higher, often synthetic doses, whereas MHT uses lower, often bioidentical doses to supplement or stabilize normal levels. Haver notes the lack of an FDA-approved bioidentical combination contraceptive in the United States (Zoely has been available in Europe since 2011).
Haver goes on to describe numerous treatment options and approaches in hormone therapy. After surgical oophorectomy (removal of the ovaries), perimenopause ends abruptly, requiring adjusted MHT. Bioidentical hormones are available as FDA-approved products or compounded preparations; the latter can vary in quality. Saliva and urine tests (e.g., DUTCH) are described as unvalidated and expensive.
Hormones can be delivered systemically (pills, patches, gels, rings, injections, or compounded creams) or locally for genitourinary symptoms. Women with a uterus using systemic estrogen need a progestogen; Haver favors continuous oral micronized progesterone for added sleep benefits and notes that transdermal progesterone creams do not adequately protect the endometrium.
No testosterone product is FDA-approved for women; off-label use of male formulations (e.g., AndroGel) at carefully adjusted doses is common. Haver criticizes testosterone pellets for being diagnosed at high levels and for unknown long-term safety, as excessive testosterone can cause irreversible effects (voice deepening, clitoral enlargement, mood swings, liver stress, and cardiovascular risks). Vaginal DHEA is approved by the FDA for genitourinary syndrome, while oral DHEA is not recommended. She then calls out products that claim to ease perimenopause through balancing vitamin intakes and cortisol levels. She firmly states that no supplement can restore ovarian hormone production or diminishing egg levels, which is the cause of perimenopause. Some women cite natural remedies, but botanical evidence is mixed.
In endometriosis, estrogen-only MHT increases recurrence risk. Combined therapy may reduce it, and tibolone is an alternative. Fibroids may initially enlarge on MHT and then stabilize; they warrant monitoring but are not a strict contraindication. She notes the importance of close monitoring and personalized treatment plans when approaching perimenopause as someone with endometriosis. The chapter urges more open, evidence-based discussion of perimenopause hormone therapy.
Allison G., a 52-year-old oncology nurse, entered perimenopause in her late forties. Standard recommendations did not help many of her patients—or her—when she developed weight gain, poor sleep, hot flashes, and anxiety. She adopted weightlifting, cardio, yoga, a high-protein diet, and sleep hygiene; she became stronger, slept better, and resolved her hot flashes. She later became a certified personal trainer to support cancer patients through fitness.
Haver addresses the gender health gap: Women live longer yet spend more years in poor health, often beginning in midlife due to systemic gaps in research and training. Social conventions surrounding women’s appearances and weight also contribute to these issues. Perimenopause is a window to prevent disease by prioritizing consistency and self-compassion—focusing not on thinness but on strength and shifting from calorie counting to prioritizing nutrient density in food. Cardiorespiratory fitness predicts health more strongly than body mass index in midlife women; resistance training supports bone, insulin sensitivity, and mental well-being.
The four fundamentals are nutrition, movement, sleep, and stress reduction. With declining estrogen, systemic inflammation rises. Haver’s anti-inflammatory approach—central to The Galveston Diet—emphasizes omega-3-rich fish, antioxidant plants (berries, crucifers), fiber from legumes and vegetables, polyphenols (green tea, turmeric), olive oil, and spices. Researchers recommend a simple strategy of aiming for 30 different plant foods weekly to foster microbial diversity. Fiber also aids estrogen metabolism; most women consume far below the 25-30 grams recommended.
Meanwhile, protein needs exceed common deficiency-prevention targets. The Women’s Health Initiative associates 1.2 g/kg with better muscle and bone health. Drawing on research and on Dr. Gabrielle Lyon’s Forever Strong, Haver suggests 1.2-1.6 g/kg for maintenance and 1.6-1.8 g/kg for building muscle, tailored to body composition. Practical tips include the plate method (half produce, one-quarter protein, one-quarter whole grains), meal prep, and mindful eating. Women should test for iron and vitamin D before supplementing. Common, purposeful supplements include vitamin D, fiber, collagen, turmeric, creatine, magnesium, and B vitamins.
Exercise protects against muscle and bone loss, metabolic dysfunction, and mood and sleep disturbances. Aim for at least 150 minutes of moderate aerobic activity and two weekly resistance sessions; include flexibility and balance work (e.g., yoga). Additionally, weighted vests during walks can support bone density.
Finally, hormonal shifts impair sleep, given that progesterone has a sedative effect, and estrogen reduces night sweats. MHT can help, alongside consistent schedules; cool, dark bedrooms; limiting caffeine/alcohol; and relaxation. Chronic stress worsens symptoms, while tools like cognitive behavioral therapy, meditation, journaling, and apps (Headspace, Calm) support self-regulation. Sustainable habits now build resilience and enhance the effectiveness of MHT.
Michelle M., nearly 43, went through five years of intermittent symptoms that intensified: Her period lengthened from four to 12 to 14 days, followed by hot flashes, night sweats, mood swings, brain fog, itchy scalp and ears, hair loss, insomnia, and overstimulation—like heightened puberty.
Haver notes how often perimenopausal concerns are dismissed. A Yale analysis found that of more than 500,000 women seeking care for significant menopausal symptoms, 60% sought medical help and 75% of them left untreated.
Preparation matters. She recommends that women schedule an early appointment with adequate time; for insurance, a perimenopause consultation should be coded as a problem-focused visit, not a wellness exam. Fast beforehand if labs are likely. Document family history (cardiovascular disease, diabetes, cancers, dementia), keep a symptom journal (sleep, mood, cognition, weight, digestion, cycle changes, energy, sexual health), clarify treatment preferences, and bring credible resources—especially since only about one in five OB-GYN residents report formal perimenopause education.
The Menopause Society states that for healthy women younger than 60 and within 10 years of menopause onset, benefits of hormone therapy generally outweigh risks. Haver supplies conversation scripts to set expectations respectfully, to advocate when “normal” labs do not match symptoms, and to request evidence-based options. Thepauselife.com offers a clinician directory with testimonials. Patients need not accept suffering as a new normal or accept blanket refusals of MHT without individualized reasoning, and they should be wary of arbitrary time limits requiring one year without a period before a woman can receive treatment. Haver describes this belief as outdated.
Haver outlines labs commonly ordered for perimenopausal patients. Standard panels assess blood counts, metabolic status, glucose control, and thyroid and vitamin D status; expanded cardiometabolic risk markers (e.g., apolipoprotein B, lipoprotein[a], high-sensitivity CRP, fasting insulin/HOMA-IR) and iron studies may be added. When indicated, she orders high-sensitivity estradiol, FSH, thyroid panels (including antibodies), inflammatory markers, and select vitamin levels, explaining how each can inform care. She also invites readers to engage with her educational content and community.
Haver writes to her 35-year-old self—busy with motherhood, marriage, and medicine—acknowledging that she’s unprepared for menopause because training prioritized thinness over strength and minimized hormonal change. When menopause arrives, she will first blame stress and then fight for clarity and purpose, reshaping her practice, priorities, and platform.
She offers five lessons. First, shift from thin to strong: Build muscle, stamina, and resilience through strength training. Second, prioritize nutrition over calories: Emphasize fiber, protein, antioxidants, and healthy fats, a philosophy that underpins The Galveston Diet. Third, learn about menopause to fill gaps in medical education and understand that hormone therapy can be appropriate. Fourth, view aging as a privilege; personal losses will teach gratitude, and she will pivot her career in her fifties and grow more fearless and authentic. Fifth, focus on function and longevity: Preserve muscle, protect the heart, and keep moving—health is not defined by weight, and success is not the same as busyness.
She encourages savoring these years, which feature immense life changes. Do not lose sight of joy, rest, and voice. Menopause will be disruptive but will also define purpose. She urges women to educate and advocate for themselves and others in this time, ensuring that perimenopause feels like the beginning of something, not the end.
The firsthand accounts in this section from Lilly R., Allison G., and Michelle M. explore age-based misdiagnoses, ineffective clinical recommendations, and a lack of navigational guidance for sudden symptom onset. Michelle describes how, despite her extreme symptoms, fear, and frustration, “[n]o one gave [her] a guidebook to navigate this” (270). These vignettes serve as evidence of systemic neglect, demonstrating how diagnostic gaps leave patients to endure severe, unpredictable symptoms without adequate medical support. This structural choice reinforces the text’s broader critique of an establishment that routinely ignores midlife women. Furthermore, the juxtaposition of Lilly R.’s plunging hormone levels against her gynecologist’s dismissal—predicated on the generalized, demographic assumption that Hispanic women do not enter perimenopause until age 49—highlights how rigid clinical guidelines fail to accommodate intersectional and individualized physiological differences. These anecdotes continue Haver’s foregrounding of lived experiences of a wide array of women, all of which occur within a harmful, sexist system.
The text challenges the rigid boundaries of menopausal treatment by targeting the limitations of current medical vocabulary, thereby reaffirming Haver’s assertion that Hormones Drive Midlife Mood and Cognition. The narrative proposes transitioning from the established term “menopause hormone therapy,” or “MHT,” to “PET hormones,” an acronym signifying progesterone, estrogen, and testosterone. This linguistic shift divorces hormone therapy from strictly menstruation, arguing that the previous terminology artificially limits care by conceptually excluding perimenopausal, postpartum, and surgically menopausal patients. The detailed breakdown of specific hormone functions anchors this proposed nomenclature in concrete biological mechanics rather than arbitrary temporal life stages. By redefining the terminology, the text emphasizes that hormone therapy “isn’t just about replacing what is lost; it’s about stabilizing what is dysregulated” (230). This reframing functions as a macro-level critique of diagnostic silos within gynecology and endocrinology. It advocates for a treatment paradigm that addresses hormonal instability as a continuous spectrum of physiological care rather than a discrete post-reproductive event, ultimately demanding a more precise and clinically inclusive lexicon for women’s healthcare that represents lived experiences.
In examining lifestyle factors, the narrative portrays perimenopause as a critical window for biological fortification rather than a period of inevitable decay. Chapter 15 emphasizes a definitive shift from pursuing thinness to building strength, detailing clinical recommendations like a weekly intake of 30 diverse plant foods, elevated protein consumption tailored to body composition, and consistent resistance training. The text deliberately discards aesthetic-driven dietary culture in favor of cellular resilience, asserting that cardiorespiratory fitness predicts midlife health outcomes far more accurately than body mass index. By emphasizing the metabolic benefits of fiber and the protective mechanisms of muscle and bone density, the text subverts traditional, patriarchal medical messaging that prioritizes a woman’s youthful appearance and proximity to an idealized weight. Instead, it replaces this outdated metric with a preventative, longevity-focused framework that champions physical autonomy, functional mobility, and robust musculoskeletal health well into the postmenopausal years.
The concluding chapter utilizes an epistolary format to synthesize the author’s dual identity as both an authoritative clinician and a vulnerable patient. The book closes with a letter directed to Haver’s 35-year-old self, a narrative device that distills the text’s core directives—such as prioritizing nutrients over calories and viewing aging as a privilege—while openly acknowledging her own initial ignorance. By admitting that she had been subtly conditioned by her medical training to overlook hormonal changes and her own symptoms, the author models the process of Confronting Medical Gaslighting required to properly navigate midlife health. This direct address allows the text to function simultaneously as a retrospective corrective to flawed medical education and a prescriptive guide for the reader’s future resilience. The letter effectively bridges the objective distance of clinical writing with deep subjective vulnerability, collapsing the traditional hierarchy between the omniscient physician and the passive patient. This epistolary closure cements the work’s overarching objective: transforming perimenopause from an isolated, pathologized biological burden into a shared catalyst for self-advocacy, biological literacy, and systemic transformation within the broader landscape of modern medicine.



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