Claire is a time-traveling 20th-century surgeon and the matriarch of the Fraser clan. An anachronism in colonial America, she applies her modern medical training to function as an army surgeon. Her curly, golden-brown hair with a silver streak mirrors her wild, untamed nature. She fiercely protects her family and constantly balances her modern perspective against the patriarchal norms of the 18th century.

Jamie is an 18th-century Highlander, warrior, and founder of Fraser's Ridge. Tall, fit, and distinguished by his red hair and dark-blue cat eyes, he possesses a strong sense of honor and duty. He accepts a commission as a general in the Continental Army, a decision that places him at odds with former friends and family members fighting for the British.

Ian is a scout for the Rebel army who struggles to reconcile his Scottish birth with his adoptive Mohawk identity. Accompanied by his wolf-dog Rollo, he is a formidable warrior with pale skin and deer-like brown eyes. His violent capabilities frequently clash with his gentle nature and his desire to build a peaceful life.

Rachel is a steadfast Quaker woman who works alongside her brother to provide medical care in the army camp. Described as a "nut-brown maiden," her serene demeanor acts as a moral compass for those around her. She firmly maintains her pacifist principles while supporting the people she loves.

William is the 9th Earl of Ellesmere and an officer in the British Army. He physically resembles Jamie Fraser with his height, red hair, and dark-blue eyes. Devastated by the discovery of his illegitimacy, he struggles with a profound identity crisis and acts out in anger, searching for a place to direct his frustrations.

John is a British nobleman and officer who married Claire out of necessity when Jamie was presumed dead. Known for his charm and sharp sense of humor, he finds himself in immediate physical and political danger when captured by Rebels. As a gay man in the 18th century, he lives under the constant threat of blackmail but remains fiercely protective of his family.

Brianna is the tall, red-haired daughter of Jamie and Claire Fraser. Possessing her father's fiery temper and her mother's pragmatism, she works as an engineer at a hydroelectric dam in the 20th century. She proves indomitable when her family is threatened, taking ruthless action to protect her children while her husband is away.

Roger is a soft-spoken minister bearing a scar on his throat from a past hanging. He travels back to 1739 in search of his missing son, operating under the heavy burden of knowing the tragic futures of the people he encounters. He continuously weighs his duty as a man of God against his desperate need to reunite his family.

Captain Richardson is a manipulative officer operating as a double agent. He uses blackmail and coercion to maneuver powerful families, specifically targeting Lord John Grey's secrets to influence British political strategies.

Janet is Jamie's strong-willed sister and Ian's mother. Grieving the loss of her husband and operating with typical Highland independence, she assists Claire with managing the household in Philadelphia. She offers pragmatic, culturally bound advice to Claire regarding life's hardships.

Hal is the Duke of Pardloe and a high-ranking British military official. He suffers from chronic asthma but refuses to let his physical limitations slow his pursuit of his missing brother. He functions as the pragmatic anchor for the Grey family, dealing with military politics and family scandals simultaneously.

Denzell is an army physician who was ousted from his Quaker meeting for his decision to join the war effort. He feels religiously called to practice medicine and heal the wounded, disregarding the political divisions of the soldiers he treats. He operates a triage wagon near the battlefields.

Dorothea is the daughter of the Duke of Pardloe who has traveled to America to be with her fiancé. Defying her aristocratic background, she actively assists Denzell and Claire in providing triage for wounded soldiers, seeking instruction on medicine and married life.

Germain is Jamie's resourceful, quick-witted young grandson. He eagerly wants to participate in the war and uses his impressive scrounging skills to feed soldiers. He briefly attaches himself to Lord John as an orderly, keeping John's true identity a secret.

Buck is Roger's time-traveling ancestor who journeys to 1739 to help find Jem. He suffers a mild heart attack traversing the stones and frequently butts heads with Roger over moral decisions. He grapples with the surreal experience of meeting his own parents in the past.

Robbie is a colleague of Brianna's who seeks a hidden cache of 18th-century gold. He abducts Jem and uses the boy as leverage, utilizing intimidation and physical violence against Brianna's family in 1980s Scotland.

Jem is the nine-year-old son of Roger and Brianna. Because he knows the location of Jamie's hidden gold, he becomes the target of a kidnapping plot. He demonstrates remarkable bravery and intelligence while attempting to escape his captors.

Mandy is Roger and Brianna's young daughter. She possesses a unique supernatural ability to sense the presence and distance of her male family members, acting as a human compass for Brianna during the search for Jem.

Brian is Jamie's father, living in 1739. He is a hospitable, honorable man who fought at Sheriffmuir. He graciously assists Roger with his search for Jem, entirely unaware of his own impending tragic fate.

Jane is a young sex worker who fiercely protects her little sister, Fanny. Fleeing the violent attention of Captain Harkness, she seeks William Ransom's protection in the military camps, relying on her wits and survival instincts to keep her sister safe.

Fanny is Jane's younger sister. Too young to protect herself in the dangerous environment of army camps and brothels, she relies entirely on Jane and William for her survival and well-being.

Fergus is a French-born printer and Jamie's foster son. He operates a print shop in Philadelphia and deals with political unrest and dangerous associates targeting his family. He maintains a fierce devotion to his wife and children.

Marsali is Fergus's wife and Jamie's stepdaughter. She is a pragmatic, brave woman who answers the door with a rifle to defend her home. She carefully hides the family's assets and navigates the dangerous environment of an occupied city.

Geillis is a time-traveling woman residing in 1739 Scotland. Known for her manipulative and seductive nature, she ensnares men in her web and guards her own secrets tightly.

Dr. McEwan is a time-traveling healer originally from 1841. He possesses a supernatural blue light that allows him to heal severe injuries, but his personal life is tragically entangled with Geillis Duncan, whom he cannot bring himself to leave.